Evidence map›Paper›PMID 33707489›Full record

ArticleScientific reports2021

Nanostructure of bioactive glass affects bone cell attachment via protein restructuring upon adsorption.

Ukrit Thamma, Tia J Kowal, Matthias M Falk, Himanshu Jain

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  8. Transformation from calcium sulfate to calcium phosphate in biological environment.Journal of materials science. Materials in medicine · 2021
    Article
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  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ukrit ThammaDepartment of Materials Science and Engineering, Lehigh University, Bethlehem, PA, 18015, USA.
Tia J KowalDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, 18015, USA.
Matthias M FalkDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, 18015, USA.
Himanshu JainDepartment of Materials Science and Engineering, Lehigh University, Bethlehem, PA, 18015, USA. H.Jain@Lehigh.edu.

Funding

SYNTHESIS AND MATURATION OF OLIGOMERIC MEMBRANE PROTEINSR01GM055725 · NIGMS · SCRIPPS RESEARCH INSTITUTE · PI FALK, MATTHIAS M · 1998 to 2013
$2.5M
NIGMS NIH HHS R01 GM055725
6 · The paper itself

Abstract

The nanostructure of engineered bioscaffolds has a profound impact on cell response, yet its understanding remains incomplete as cells interact with a highly complex interfacial layer rather than the material itself. For bioactive glass scaffolds, this layer comprises of silica gel, hydroxyapatite (HA)/carbonated hydroxyapatite (CHA), and absorbed proteins-all in varying micro/nano structure, composition, and concentration. Here, we examined the response of MC3T3-E1 pre-osteoblast cells to 30 mol% CaO-70 mol% SiO

Indexed as

AdsorptionAnimalsCarbonatesCell AdhesionCell CountCell LineCell SizeDurapatiteGlassMiceNanoporesNanostructuresOsteocytesProteinsProtein Structure, SecondarySerum Albumin, BovineCarbonatesDurapatiteProteinsSerum Albumin, Bovine

Identifiers

PMID33707489
PMCPMC7952393

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.