ArticleScientific reports2021
Elevated levels of mitochondrial CoQ
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Redox-modulation of regulated cell death: implications for synergistic anticancer therapies.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- The Redox Paradox of Natural Supplements in Cancer: A Narrative Review to Guide Clinical Practice.Antioxidants (Basel, Switzerland) · 2026Review
- BPM31510 Increases the CoQ Pool in Chemically Induced CoQ-Deficient Cells, CoQ-Deficient Patient Fibroblasts, and in Metabolically Active Murine Tissues.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Coenzyme Q10 exerts anti-cancer effects in bladder cancer by inducing ROS-mediated apoptosis and autophagy.Journal of bioenergetics and biomembranes · 2026Article
- Comparative review of translational approaches in lipid-based and water-based encapsulation strategies for coenzyme Q10.Drug delivery and translational research · 2026Review
- Mycobacterial respiratory chain enzymes and growth are inhibited by decylubiquinone.Communications biology · 2025Article
- Phase Ia/b Multicenter Study of BPM31510IV Targeting Mitochondrial Metabolism/Warburg Effect as Monotherapy and Combination Chemotherapy in Solid Tumor Patients.Cancer research communications · 2025Article
- A narrative literature review about alpha-lipoic acid role in dry eye and ocular surface disease.Acta ophthalmologica · 2025Review
- Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation.Journal of the Egyptian National Cancer Institute · 2025Article
- Facts, Dogmas, and Unknowns About Mitochondrial Reactive Oxygen Species in Cancer.Antioxidants (Basel, Switzerland) · 2024Review
- Auxiliary effect of trolox on coenzyme QScientific reports · 2024Article
- Understanding coenzyme Q.Physiological reviews · 2024Review
- Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival.World journal of gastroenterology · 2024Article
- Selpercatinib combination with the mitochondria-targeted antioxidant MitoQ effectively suppresses RET-mutant thyroid cancer.NPJ precision oncology · 2024Article
- Effects of arginine on coenzyme-Q10 micelle uptake for mitochondria-targeted nanotherapy in phenylketonuria.Drug delivery and translational research · 2024Article
- An oviduct glycan increases sperm lifespan by diminishing the production of ubiquinone and reactive oxygen species†.Biology of reproduction · 2023Article
- Changes in CoQInternational journal of molecular sciences · 2022Article
- Advances in Delivering Oxidative Modulators for Disease Therapy.Research (Washington, D.C.) · 2022Review
- Biomolecules resveratrol + coenzyme Q10 recover the cell state of human mesenchymal stem cells after 1-methyl-4-phenylpyridinium-induced damage and improve proliferation and neural differentiation.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
27 authors at 2 institutions in 1 country.
Tulin Dadali *BERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Anne R Diers *BERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Shiva KazerounianBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Senthil K MuthuswamyDepartment of Medicine, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Pallavi AwateBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Ryan NgBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Saie MogreBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Carrie SpencerBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Katerina KrumovaBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Hannah E RockwellBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Justice McDanielBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Emily Y ChenBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Fei GaoBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Karl T DiedrichBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Vijetha VemulapalliBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Leonardo O RodriguesBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Viatcheslav R AkmaevBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Khampaseuth ThapaBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Manuel HidalgoDepartment of Medicine, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Arindam BoseDepartment of Medicine, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Vivek K VishnudasBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
A James MoserDepartment of Medicine, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Elder GrangerBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Michael A KiebishBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Stephane GestaBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Niven R NarainBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA.
Rangaprasad SarangarajanBERG LLC, 500 Old Connecticut Path, Bldg B, 3rd Floor, Framingham, MA, 01710, USA. Rangaprasad.Sarangarajan@BergHealth.com.
Cancer Research Institute · USBeth Israel Deaconess Medical Center · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species (ROS) are implicated in triggering cell signalling events and pathways to promote and maintain tumorigenicity. Chemotherapy and radiation can induce ROS to elicit cell death allows for targeting ROS pathways for effective anti-cancer therapeutics. Coenzyme Q
Indexed as
ApoptosisAnimalsCell Line, TumorCell ProliferationCell RespirationCell SurvivalElectron Transport Complex IIGlycerol-3-Phosphate Dehydrogenase (NAD+)HumansMembrane Potential, MitochondrialMiceMice, NudeMitochondriaOrganoidsOxidative StressOxygen Consumptioncoenzyme Q10Electron Transport Complex IIGlycerol-3-Phosphate Dehydrogenase (NAD+)Reactive Oxygen SpeciesUbiquinone
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.