Evidence map›Paper›PMID 33707475›Full record

Trial reportScientific reports2021

Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study.

Rebekah L I Crake, Matthew R Strother, Elisabeth Phillips, Matthew P Doogue, Mei Zhang, Chris M A Frampton, Bridget A Robinson, Margaret J Currie

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rebekah L I CrakeMackenzie Cancer Research Group, Christchurch, Department of Pathology and Biomedical Science, University of Otago Christchurch, 2 Riccarton Avenue, PO Box 4345, Christchurch, 8011, New Zealand. rebekah.crake@otago.ac.nz.
Matthew R StrotherMackenzie Cancer Research Group, Christchurch, Department of Pathology and Biomedical Science, University of Otago Christchurch, 2 Riccarton Avenue, PO Box 4345, Christchurch, 8011, New Zealand.
Elisabeth PhillipsMackenzie Cancer Research Group, Christchurch, Department of Pathology and Biomedical Science, University of Otago Christchurch, 2 Riccarton Avenue, PO Box 4345, Christchurch, 8011, New Zealand.
Matthew P DoogueDepartment of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
Mei ZhangDepartment of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
Chris M A FramptonDepartment of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
Bridget A RobinsonMackenzie Cancer Research Group, Christchurch, Department of Pathology and Biomedical Science, University of Otago Christchurch, 2 Riccarton Avenue, PO Box 4345, Christchurch, 8011, New Zealand.
Margaret J CurrieMackenzie Cancer Research Group, Christchurch, Department of Pathology and Biomedical Science, University of Otago Christchurch, 2 Riccarton Avenue, PO Box 4345, Christchurch, 8011, New Zealand.
University of Otago · NZCanterbury District Health Board · NZCanterbury Health Laboratories · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individual response to chemotherapy in patients with breast cancer is variable. Obesity and exercise are associated with better and worse outcomes, respectively, and it is known that both impact the systemic cytokine milieu. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of many chemotherapy agents, and CYP enzyme activity has been shown to be modified by inflammatory cytokines in vitro and in vivo. Cytokine-associated changes in CYP metabolism may alter chemotherapy exposure, potentially affecting treatment response and patient survival. Therefore, better understanding of these biological relationships is required. This exploratory single arm open label trial investigated changes in in vivo CYP activity in twelve women treated for stage II or III breast cancer, and demonstrated for the first time the feasibility and safety of utilising the Inje phenotyping cocktail to measure CYP activity in cancer patients receiving chemotherapy. Relative CYP activity varied between participants, particularly for CYP2C9 and CYP2D6, and changes in serum concentrations of the inflammatory cytokine monocyte chemoattractant protein 1 inversely correlated to CYP3A4 activity during chemotherapy. Future use of phenotyping cocktails in a clinical oncology setting may help guide drug dosing and improve chemotherapy outcomes.Clinical Trial Registration: Trial was retrospectively registered to the Australia New Zealand Clinical Trial Registry (ANZCTR). ACTRN12620000832976, 21 Aug 2020, https://www.anzctr.org.au/ACTRN12620000832976.aspx .

Indexed as

Antineoplastic AgentsBreast NeoplasmsCytochrome P-450 Enzyme SystemCytokinesFeasibility StudiesFemaleHumansInflammation MediatorsAntineoplastic AgentsCytochrome P-450 Enzyme SystemCytokinesInflammation Mediators

Identifiers

PMID33707475
PMCPMC7952716
OpenAlexW3135097309

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.