ArticleNature communications2021
A randomised controlled trial to reduce highest priority critically important antimicrobial prescription in companion animals.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Prevalence of antibiotic use in dogs and cats in US and Canadian veterinary teaching hospitals, 2022.Journal of veterinary internal medicine · 2026Article
- Reusing health records from farm animal practices at scale: A potential complementary method of surveillance.The Veterinary record · 2026Article
- A structured, behavioural science approach to the preparation of antimicrobial stewardship interventions for companion animal veterinarians.The Veterinary record · 2026Article
- Commensal and opportunistic bacteria resistant to fourth-generation cephalosporins or fluoroquinolones isolated from yellow-legged gulls (Larus michahellis) settled in Taranto, Southern Italy.Scientific reports · 2026Article
- Factors associated with antimicrobial drug prescription in dogs receiving outpatient care at a veterinary teaching hospital.Journal of veterinary internal medicine · 2026Article
- Benchmarking: A Tool for Veterinary Practices to Improve Prudent Use of Antibiotics in Cats and Dogs in Switzerland.Antibiotics (Basel, Switzerland) · 2026Article
- Antimicrobial prescribing in dogs and cats with urinary tract disease in a prospective intervention trial.Journal of veterinary internal medicine · 2026Article
- Companion Animals Harbour Globally Circulating Human-Associated Klebsiella pneumoniae Lineages and High-Risk Antimicrobial Resistance Clones.Transboundary and emerging diseases · 2026Article
- Multiscale Plant Defense Strategies against Ciprofloxacin Stress: From Chloroplast-Centered Adaptation to Microbiome Coordination.Research (Washington, D.C.) · 2026Article
- Enrofloxacin-associated ocular disease in cats: A scoping review.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Antimicrobial use in animals: When more might be better.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Factors associated with the use of important human antimicrobials in Japanese small-animal clinics.Frontiers in veterinary science · 2025Article
- Article
- Patient weight has diverse effects on the prescribing of different antibiotics to dogs.Frontiers in veterinary science · 2024Article
- Examining the Veterinary Electronic Antimicrobial Prescriptions for Dogs and Cats in the Campania Region, Italy: Corrective Strategies Are Imperative.Animals : an open access journal from MDPI · 2023Article
- The potential role of veterinary technicians in promoting antimicrobial stewardship.BMC veterinary research · 2023Article
- 'Brave Enough': A Qualitative Study of Veterinary Decisions to Withhold or Delay Antimicrobial Treatment in Pets.Antibiotics (Basel, Switzerland) · 2023Article
- Article
- Behavior-change interventions to improve antimicrobial stewardship in human health, animal health, and livestock agriculture: A systematic review.PLOS global public health · 2023Article
- Antimicrobial stewardship in companion animal practice: an implementation trial in 135 general practice veterinary clinics.JAC-antimicrobial resistance · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Robust evidence supporting strategies for companion animal antimicrobial stewardship is limited, despite frequent prescription of highest priority critically important antimicrobials (HPCIA). Here we describe a randomised controlled trial where electronic prescription data were utilised (August 2018-January 2019) to identify above average HPCIA-prescribing practices (n = 60), which were randomly assigned into a control group (CG) and two intervention groups. In March 2019, the light intervention group (LIG) and heavy intervention group (HIG) were notified of their above average status, and were provided with educational material (LIG, HIG), in-depth benchmarking (HIG), and follow-up meetings (HIG). Following notification, follow-up monitoring lasted for eight months (April-November 2019; post-intervention period) for all intervention groups, though HIG practices were able to access further support (i.e., follow-up meetings) for the first six of these months if requested. Post-intervention, in the HIG a 23.5% and 39.0% reduction in canine (0.5% of total consultations, 95% confidence interval, 0.4-0.6, P = 0.04) and feline (4.4%, 3.4-5.3, P < 0.001) HPCIA-prescribing consultations was observed, compared to the CG (dogs: 0.6%, 0.5-0.8; cats: 7.4%, 6.0-8.7). The LIG was associated with a 16.7% reduction in feline HPCIA prescription (6.1% of total consultations, 5.3-7.0, P = 0.03). Therefore, in this trial we have demonstrated effective strategies for reducing veterinary HPCIA prescription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.