Evidence map›Paper›PMID 33707347›Full record

ArticleExperimental neurobiology2021

Dynamics of T Lymphocyte between the Periphery and the Brain from the Acute to the Chronic Phase Following Ischemic Stroke in Mice.

Minha Kim, So-Dam Kim, Kyoung In Kim, Eun Hae Jeon, Min Gee Kim, Yu-Ree Lim, Enkhmaa Lkhagva-Yondon, Yena Oh, Kwangmin Na, Young Cheul Chung and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Experimental neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Updates of the role of B-cells in ischemic stroke.Frontiers in cellular neuroscience · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Inflammatory Responses After Ischemic Stroke.Seminars in immunopathology · 2022
    Review
  12. Antioxidants (Basel, Switzerland) · 2021
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Minha KimTranslational Research Center, Department of Molecular Biomedicine, IRIMS, and College of Medicine, Inha University, Incheon 22332, Korea.
So-Dam KimCollege of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
Kyoung In KimDepartment of Biochemistry & Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
Eun Hae JeonTranslational Research Center, Department of Molecular Biomedicine, IRIMS, and College of Medicine, Inha University, Incheon 22332, Korea.
Min Gee KimCollege of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
Yu-Ree LimTranslational Research Center, Department of Molecular Biomedicine, IRIMS, and College of Medicine, Inha University, Incheon 22332, Korea.
Enkhmaa Lkhagva-YondonTranslational Research Center, Department of Molecular Biomedicine, IRIMS, and College of Medicine, Inha University, Incheon 22332, Korea.
Yena OhTranslational Research Center, Department of Molecular Biomedicine, IRIMS, and College of Medicine, Inha University, Incheon 22332, Korea.
Kwangmin NaTranslational Research Center, Department of Molecular Biomedicine, IRIMS, and College of Medicine, Inha University, Incheon 22332, Korea.
Young Cheul ChungDepartment of Biochemistry & Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
Byung Kwan JinDepartment of Biochemistry & Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
Yun Seon SongCollege of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
Myung-Shin JeonTranslational Research Center, Department of Molecular Biomedicine, IRIMS, and College of Medicine, Inha University, Incheon 22332, Korea.
Inha University · KRSookmyung Women's University · KRKyung Hee University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke causes systemic immunosuppression. T lymphocytes are involved in infarct size in the early stages of stroke. However, the phenotypes of T lymphocytes and their functions in peripheral immune organs and the brain have not been well analyzed in the acute and chronic phases of stroke. Here, we investigated pathological phenotypic alterations in the systemic immune response, especially changes in T lymphocytes, from one day to six months after ischemic stroke in mice. Impairment in thymocyte numbers, development, proliferation, and apoptosis were observed for up to two weeks. The number of mature T cells in the spleen and blood decreased and showed reduced interferon-γ production. Increased numbers of CD4

Indexed as

Foxp3IL-10Ischemic strokeRegulatory T cellsThymocyteT lymphocytes

Identifiers

PMID33707347
PMCPMC8118758
OpenAlexW3113193020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.