ArticleScience (New York, N.Y.)2021
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 3 pooled it
14.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 3 syntheses or guidelines pooled it, 210 citations in OpenAlex.
- Biomarkers in the pathogenesis and diagnosis of Crohn's perianal fistulas: a systematic review.Techniques in coloproctology · 2026Pooled it
- Intestinal fungal signatures and their impact on immune checkpoint inhibitor efficacy: a multi-cohort meta-analysis.NPJ biofilms and microbiomes · 2025Pooled it
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- Specific fungi associated with response to capsulized fecal microbiota transplantation in patients with active ulcerative colitis.Frontiers in cellular and infection microbiology · 2022Trial
- Neglected kingdoms: the gut virome, mycobiome and their role in inflammatory bowel disease.Gut microbes · 2026Review
- The gut microbiota as a regulator of intestinal stem-cell fate: bacterial and fungal control of differentiation and regeneration.Gut microbes · 2026Review
- The role ofmBio · 2026Article
- Innate immune recognition ofInfection and immunity · 2026Article
- Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade.eLife · 2026Article
- Antifungal therapy improves microbiome dynamics in inflammatory bowel disease.Nature medicine · 2026Observational
- Review
- Article
- Diet, Gut Microbiome, and Microbial Metabolites in Inflammatory Bowel Disease: From Functional Dysbiosis to Precision Nutrition.International journal of molecular sciences · 2026Review
- Disrupted Salivary Fungal Community in Patients With Oral Lichen Planus.International dental journal · 2026Article
- Colonic Engyodontium fungus triggers neutrophil antimicrobial activity to suppress Lactobacillus johnsonii-derived glutamic acid-maintained Tregs.The Journal of clinical investigation · 2026Article
- Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to DSS-Induced Colitis.Immunology · 2026Article
- Urinary Fungal Microbiome and Associations With Overactive Bladder, Antibiotics and Therapy Response.Neurourology and urodynamics · 2026Article
- Mycobiome dysbiosis and genetic predisposition to elevated IL-17A contribute to fibrosis in MASLD.JHEP reports : innovation in hepatology · 2026Article
- Gut mucosal mycobiome profiling in Crohn's disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum.Nature metabolism · 2026Article
- Mucosal fungal dysbiosis is associated with early postoperative endoscopic recurrence after bowel resection for Crohn's disease.International journal of colorectal disease · 2026Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 1 country.
Umang JainDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-0220-8230
Aaron M Ver HeulDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0003-3386-8351
Shanshan XiongDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0003-1229-4600
Martin H GregoryDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-6656-9828
Elora G DemersDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.ORCID https://orcid.org/0000-0002-1709-7430
Justin T KernDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chin-Wen LaiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-7691-009X
Brian D MueggeDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-0044-3704
Derek A G BarisasDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0003-0707-2659
J Steven Leal-EkmanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-4247-0647
Parakkal DeepakDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-3436-9784
Matthew A CiorbaDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-7656-0982
Ta-Chiang LiuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-2800-9360
Deborah A HoganDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.ORCID https://orcid.org/0000-0002-6366-2971
Philip DebbasF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID https://orcid.org/0000-0002-7220-2117
Jonathan BraunF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Dermot P B McGovernF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
David M UnderhillF. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID https://orcid.org/0000-0002-2989-658X
Thaddeus S StappenbeckDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. stappet@ccf.org.ORCID https://orcid.org/0000-0002-6023-3901
Washington University in St. Louis · USCedars-Sinai Medical Center · USDartmouth College · USAmgen (United States) · USCleveland Clinic · US
Funding
Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1MEvolved Heterogeneity Contributes to Chronic Fungal Lung InfectionsR01AI127548 · NIAID · DARTMOUTH COLLEGE · PI HOGAN, DEBORAH A · 2017 to 2025
$3.9MTunable therapeutic modulation of the gut microbiome by engineered probioticsR01AT009741 · NCCIH · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, MOON, TAE SEOK · 2018 to 2022
$3.5MSystemic Neurotropic virus infection effects on GI DysmotilityR01DK122790 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI DIAMOND, MICHAEL S, HANDLEY, SCOTT A. · 2020 to 2023
$2.7MTARGETING TRYPTOPHAN METABOLISM IN COLITIS ASSOCIATED CANCERR01DK109384 · NIDDK · WASHINGTON UNIVERSITY · PI CIORBA, MATTHEW AARON · 2016 to 2020
$1.7MCellular and molecular mechanisms of cigarette smoking-induced Paneth cell abnormalityR01DK125296 · NIDDK · WASHINGTON UNIVERSITY · PI LIU, TA-CHIANG · 2020 to 2023
$1.4MBLRD VA IK2 BX004909NCCIH NIH HHS R01 AT009741NIAID NIH HHS R01 AI127548NIDDK NIH HHS P01 DK046763NIDDK NIH HHS R01 DK122790NIDDK NIH HHS R01 DK125296
Abstract
Alterations of the mycobiota composition associated with Crohn's disease (CD) are challenging to link to defining elements of pathophysiology, such as poor injury repair. Using culture-dependent and -independent methods, we discovered that
Indexed as
Amphotericin BAnimalsAnti-Bacterial AgentsAntifungal AgentsChemokine CCL5ColonCrohn DiseaseDebaryomycesFemaleGastrointestinal MicrobiomeGerm-Free LifeHumansIleumInflammationInterferon Type IIntestinal MucosaAmphotericin BAnti-Bacterial AgentsAntifungal AgentsCcl5 protein, mouseChemokine CCL5Interferon Type I
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.