ArticleProceedings of the National Academy of Sciences of the United States of America2021
Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- An ultra-sensitive multi-channel MEG system for the non-invasive single-trial detection of cortical population spikes.Scientific reports · 2026Article
- Excitability Modulations of Somatosensory Perception Do Not Depend on Feedforward Neuronal Population Spikes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation.bioRxiv : the preprint server for biology · 2025Article
- Prior knowledge changes initial sensory processing in the human spinal cord.Science advances · 2025Article
- Fast Degaussing Procedure for a Magnetically Shielded Room.Materials (Basel, Switzerland) · 2024Article
- First activity and interactions in thalamus and cortex using raw single-trial EEG and MEG elicited by somatosensory stimulation.Frontiers in systems neuroscience · 2023Article
- Separating Neural Oscillations from Aperiodic 1/f Activity: Challenges and Recommendations.Neuroinformatics · 2022Article
- Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal spiking is commonly recorded by invasive sharp microelectrodes, whereas standard noninvasive macroapproaches (e.g., electroencephalography [EEG] and magnetoencephalography [MEG]) predominantly represent mass postsynaptic potentials. A notable exception are low-amplitude high-frequency (∼600 Hz) somatosensory EEG/MEG responses that can represent population spikes when averaged over hundreds of trials to raise the signal-to-noise ratio. Here, a recent leap in MEG technology-featuring a factor 10 reduction in white noise level compared with standard systems-is leveraged to establish an effective single-trial portrayal of evoked cortical population spike bursts in healthy human subjects. This time-resolved approach proved instrumental in revealing a significant trial-to-trial variability of burst amplitudes as well as time-correlated (∼10 s) fluctuations of burst response latencies. Thus, ultralow-noise MEG enables noninvasive single-trial analyses of human cortical population spikes concurrent with low-frequency mass postsynaptic activity and thereby could comprehensively characterize cortical processing, potentially also in diseases not amenable to invasive microelectrode recordings.
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