Evidence map›Paper›PMID 33707203›Full record

ArticleeNeuro

Differential Impact of Inhibitory G-Protein Signaling Pathways in Ventral Tegmental Area Dopamine Neurons on Behavioral Sensitivity to Cocaine and Morphine.

Margot C DeBaker, Ezequiel Marron Fernandez de Velasco, Nora M McCall, Anna M Lee, Kevin Wickman

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. GABAMedComm · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Margot C DeBakerGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455.
Ezequiel Marron Fernandez de VelascoDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0003-0257-4457
Nora M McCallGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455.
Anna M LeeDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455.
Kevin WickmanDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455 wickm002@umn.edu.ORCID 0000-0002-5179-9540
University of Minnesota · US

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Paul G Mermelstein · 2020 to 2026
$19.0M
NEUROSCIENCE TRAINING IN DRUG ABUSE RESEARCHT32DA007234 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Paul G Mermelstein, Jocelyn M Richard · 1986 to 2026
$10.9M
Relevance and plasticity of inhibitory metabotropic signaling in reward circuitsR01DA034696 · NIDA · UNIVERSITY OF MINNESOTA · PI WICKMAN, KEVIN D · 2013 to 2022
$3.4M
Dissecting nicotinic receptor contributions to alcohol aversionR01AA026598 · NIAAA · UNIVERSITY OF MINNESOTA · PI LEE, ANNA M. · 2018 to 2022
$1.7M
Alcohol-related suppression of GIRK channel activity in the basal amygdala: a link to plasticity of glutamatergic neurotransmission and withdrawal-associated behavior?R01AA027544 · NIAAA · UNIVERSITY OF MINNESOTA · PI WICKMAN, KEVIN D · 2020 to 2024
$1.7M
Cocaine-induced adaptations in inhibitory signaling in VTA dopamine neuronsF31DA041767 · NIDA · UNIVERSITY OF MINNESOTA · PI MCCALL, NORA · 2016 to 2018
$116k
GABAB receptor-dependent signaling in alcohol consumption and rewardF31AA028726 · NIAAA · UNIVERSITY OF MINNESOTA · PI DEBAKER, MARGOT CLARA · 2021 to 2021
$31k
NIAAA NIH HHS F31 AA028726NIAAA NIH HHS R01 AA026598NIAAA NIH HHS R01 AA027544NIDA NIH HHS F31 DA041767NIDA NIH HHS P30 DA048742NIDA NIH HHS R01 DA034696NIDA NIH HHS T32 DA007234
6 · The paper itself

Abstract

Drugs of abuse engage overlapping but distinct molecular and cellular mechanisms to enhance dopamine (DA) signaling in the mesocorticolimbic circuitry. DA neurons of the ventral tegmental area (VTA) are key substrates of drugs of abuse and have been implicated in addiction-related behaviors. Enhanced VTA DA neurotransmission evoked by drugs of abuse can engage inhibitory G-protein-dependent feedback pathways, mediated by GABA

Indexed as

CocaineVentral Tegmental AreaAnimalsDopaminergic NeuronsFemaleGTP-Binding ProteinsMaleMiceMorphineCocaineGTP-Binding ProteinsMorphinecocaineCRISPRD2 dopamine receptorGABAB receptormorphinesex differences

Identifiers

PMID33707203
PMCPMC8114902
OpenAlexW3134587224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.