Evidence map›Paper›PMID 33707120›Full record

ArticleBrazilian journal of otorhinolaryngology

AIM2 inflammasome activation may mediate high mobility group box 1 release in murine allergic rhinitis.

Yan Wang, Shan Chen, Ping-Li Yang, Jian-Jun Chen, Wei-Jia Kong, Yan-Jun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Involvement of the pyroptosis-HMGB1 axis in systemic diseases.Frontiers in cell and developmental biology · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yan WangHuazhong University of Science and Technology, Tongji Medical College, Union Hospital, Department of Otorhinolaryngology, Wuhan, China.
Shan ChenHuazhong University of Science and Technology, Tongji Medical College, Union Hospital, Department of Otorhinolaryngology, Wuhan, China.
Ping-Li YangShihezi University School of Medicine, The First Affiliated Hospital, Department of Otorhinolaryngology, Shihezi, China.
Jian-Jun ChenHuazhong University of Science and Technology, Tongji Medical College, Union Hospital, Department of Otorhinolaryngology, Wuhan, China.
Wei-Jia KongHuazhong University of Science and Technology, Tongji Medical College, Union Hospital, Department of Otorhinolaryngology, Wuhan, China; Huazhong University of Science and Technology, Tongji Medical College, Union Hospital, Institute of Otorhinolaryngology, Wuhan, China. Electronic address: entwjkong@hust.edu.cn.
Yan-Jun WangHuazhong University of Science and Technology, Tongji Medical College, Union Hospital, Department of Otorhinolaryngology, Wuhan, China; Huazhong University of Science and Technology, Tongji Medical College, Union Hospital, Institute of Otorhinolaryngology, Wuhan, China. Electronic address: yjwang@hust.edu.cn.
Union Hospital · CNShihezi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHigh mobility group box 1 protein participates in the pathogenesis of allergic rhinitis. Activation of the inflammasome can mediate the release of high mobility group box 1. The role of the absent in melanoma 2 inflammasome in allergic rhinitis remains unclear.

objectiveThis study aimed to investigate the function of absent in melanoma 2 inflammasome in murine allergic rhinitis and the interaction between high mobility group box 1 and the absent in melanoma 2 inflammasome.

methodsA murine allergic rhinitis model was established using twenty Balb/c mice. Expression of the components of the absent in melanoma 2 inflammasome: absent in melanoma 2, apoptosis-associated speck-like protein containing a CARD (Asc), caspase-1 p20, and additional nod-like receptor family pyrin domain containing 3 (Nlrp3) were detected by western blotting during allergic rhinitis. Alterations of absent in melanoma 2, caspase-1, and high mobility group box 1 after ovalbumin challenge were demonstrated by immunohistochemistry. TdT-mediated dUTP Nick end labeling, TUNEL assay, and cleavage of caspase-3 and PARP-1 were used for the observation of pyroptosis.

resultsEosinophilia and goblet cell infiltration were observed in the nasal mucosa of mice in the allergic rhinitis group. Absent in melanoma 2, Asc, and caspase-1 p20 increased after ovalbumin exposure while Nlrp3 did not. High mobility group box 1 was released in the nasal mucosa of allergic rhinitis mice. TUNEL-positive cells increased in the epithelium and laminae propria, whereas cleavage of caspase-3 and PARP-1 was not observed.

conclusionsThe absent in melanoma 2 inflammasome was activated and pyroptosis may occur in the nasal mucosa after ovalbumin treatment. These may contribute to the translocation of high mobility group box 1 and the development of allergic rhinitis.

Indexed as

DNA-Binding ProteinsHMGB1 ProteinRhinitis, AllergicAnimalsCaspase 1Caspase 3InflammasomesMiceMice, Inbred BALB CNLR Family, Pyrin Domain-Containing 3 ProteinOvalbuminAim2 protein, mouseCaspase 1Caspase 3DNA-Binding ProteinsHMGB1 ProteinHMGB1 protein, mouseInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinOvalbuminAIM2Allergic rhinitisCaspase-1InflammasomeNlrp3Pyroptosis

Identifiers

PMID33707120
PMCPMC9615526
OpenAlexW3132456612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.