Evidence map›Paper›PMID 33706918›Full record

ReviewCurrent topics in developmental biology2021

Dorsal commissural axon guidance in the developing spinal cord.

Sandy Alvarez, Supraja G Varadarajan, Samantha J Butler

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current topics in developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sandy AlvarezDepartment of Neurobiology, University of California, Los Angeles, CA, United States; Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, CA, United States.
Supraja G VaradarajanDepartment of Neurobiology, Stanford University, Palo Alto, CA, United States.
Samantha J ButlerDepartment of Neurobiology, University of California, Los Angeles, CA, United States; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, United States. Electronic address: butlersj@ucla.edu.
University of California, Los Angeles · USStanford University · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Assessing the contact-mediated role of netrin1 in axon guidanceR01NS107509 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTLER, SAMANTHA J · 2019 to 2023
$2.2M
Diverse roles of the Bone Morphogenetic Proteins in the developing spinal cordR01NS085097 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTLER, SAMANTHA J · 2014 to 2018
$1.7M
Investigating netrin1-mediated commissural axon guidance in the developing spinal cordF31NS120563 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALVAREZ, SANDY · 2020 to 2022
$71k
NIGMS NIH HHS T32 GM007185NINDS NIH HHS F31 NS120563NINDS NIH HHS R01 NS085097NINDS NIH HHS R01 NS107509
6 · The paper itself

Abstract

Commissural axons have been a key model system for identifying axon guidance signals in vertebrates. This review summarizes the current thinking about the molecular and cellular mechanisms that establish a specific commissural neural circuit: the dI1 neurons in the developing spinal cord. We assess the contribution of long- and short-range signaling while sequentially following the developmental timeline from the birth of dI1 neurons, to the extension of commissural axons first circumferentially and then contralaterally into the ventral funiculus.

Indexed as

Axon GuidanceSpinal CordAnimalsAxonsNeuronsAxon guidanceBMPChemotaxisCommissural axonsEphrinFloor plateHaptotaxisNetrin1Neural developmentRoboRoof plateSlit

Identifiers

PMID33706918
PMCPMC9109821
OpenAlexW3108465191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.