Evidence map›Paper›PMID 33706704›Full record

ArticleBMC cardiovascular disorders2021

IGFBP-1 and IGFBP-2 are associated with a decreased pulse-wave velocity in young, healthy adults.

Paul Pettersson-Pablo, Torbjörn K Nilsson, Lars H Breimer, Anita Hurtig-Wennlöf

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Proteome-Wide Genetic Investigation of Large Artery Stiffness.JACC. Basic to translational science · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Paul Pettersson-PabloDepartment of Laboratory Medicine, Clinical Chemistry, Faculty of Medicine and Health, Örebro University Hospital, Södra Grevrosengatan 1, 703 62, Örebro, Sweden. paul.pettersson-pablo@regionorebrolan.se.
Torbjörn K NilssonDepartment of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden.
Lars H BreimerDepartment of Laboratory Medicine, Clinical Chemistry, Faculty of Medicine and Health, Örebro University Hospital, Södra Grevrosengatan 1, 703 62, Örebro, Sweden.
Anita Hurtig-WennlöfSchool of Health, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Jönköping University · SEÖrebro University · SEÖrebro University Hospital · SEUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsIn healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals.

methodsWe employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18-26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT).

resultsThree principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements.

conclusionsIn this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years.

Indexed as

Pulse Wave AnalysisVascular StiffnessAdolescentAdultAge FactorsBiomarkersCardiovascular DiseasesCarotid Intima-Media ThicknessCross-Sectional StudiesEarly DiagnosisFemaleHealthy VolunteersHumansInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 2MaleBiomarkersIGFBP1 protein, humanIGFBP2 protein, humanInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 2ProteomecIMTPrincipal component analysisProteomicsVascular stiffness

Identifiers

PMID33706704
PMCPMC7949246
OpenAlexW3135215969

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.