Evidence map›Paper›PMID 33706697›Full record

ArticleBMC nephrology2021

Beta-trace protein as a potential biomarker of residual renal function in patients undergoing peritoneal dialysis.

Sebastian Schwab, Carola Ellen Kleine, Dominik Bös, Sylvie Bohmann, Christian P Strassburg, Philipp Lutz, Rainer Peter Woitas

Open access · goldAbstract read
In one paragraph

Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Comparison of BTP, NGAL, KIM-1, & ADMA biomarkers in CKD and non-CKD subjects.International journal of biochemistry and molecular biology · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sebastian SchwabDepartment of Internal Medicine I, University of Bonn, Bonn, Germany. sebastian.schwab@ukbonn.de.
Carola Ellen KleineDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Dominik BösKfH, Renal Center, Bonn, Germany.
Sylvie BohmannKfH, Renal Center, Bonn, Germany.
Christian P StrassburgDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Philipp Lutz *Department of Internal Medicine I, University of Bonn, Bonn, Germany.
Rainer Peter Woitas *Diaverum Deutschland GmbH, Munich, Germany.
University of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResidual renal function is closely linked to quality of life, morbidity and mortality in dialysis patients. Beta-trace protein (BTP), a low molecular weight protein, has been suggested as marker of residual renal function, in particular in patients on hemodialysis. We hypothesized that BTP also serves as a marker of residual renal function in pertioneal dialysis patients.

methodsIn this study 34 adult patients on peritoneal dialysis were included. BTP, creatinine, cystatin C and urea concentrations were analyzed simultaneously in serum and dialysate to calculate renal and peritoneal removal of the analytes.

resultsIn peritoneal dialysis patients with residual diuresis, mean serum BTP was 8.16 mg/l (SD ± 4.75 mg/l). BTP correlated inversely with residual diuresis (r

conclusionBTP measurement in the serum may be a simple tool to assess residual renal function in peritoneal dialysis patients.

Indexed as

Peritoneal DialysisAdultBiomarkersFemaleHumansIntramolecular OxidoreductasesKidneyLipocalinsMaleMiddle AgedProspective StudiesRenal Insufficiency, ChronicBiomarkersIntramolecular OxidoreductasesLipocalinsprostaglandin R2 D-isomeraseBeta-trace proteinLow-molecular weight proteinsPeritoneal dialysisResidual diuresis

Identifiers

PMID33706697
PMCPMC7953776
OpenAlexW3135849335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.