ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Identification and Validation of Distinct Latent Neurodevelopmental Profiles in the Adolescent Brain and Cognitive Development Study.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Interrogating cognitive and neural group variation in childhood: Examples in adolescent brain cognitive development and Oregon attention-deficit/hyperactivity disorder-1000 cohorts.Journal of psychopathology and clinical science · 2026Article
- A comparative study of state self-esteem responses to social media feedback loops in adolescents and adults.Frontiers in psychology · 2025Article
- Integrating data science and neuroscience in developmental psychopathology: Formative examples and future directions.Development and psychopathology · 2024Article
- Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework.NeuroImage · 2024Article
- Stimulant medications in children with ADHD normalize the structure of brain regions associated with attention and reward.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder.The American journal of drug and alcohol abuse · 2024Article
- Neurodevelopmental Subtypes of Functional Brain Organization in the ABCD Study Using a Rigorous Analytic Framework.bioRxiv : the preprint server for biology · 2024Article
- Developmental deviation in delay discounting as a transdiagnostic indicator of risk for child psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Digital Media and Developing Brains: Concerns and Opportunities.Current addiction reports · 2024Review
- Longitudinal relationships between lifestyle risk factors and neurodevelopment in early adolescence.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Screen media activity in youth: A critical review of mental health and neuroscience findings.Journal of mood and anxiety disorders · 2023Article
- Developmental Milestones of Infancy and Associations with Later Childhood Neurodevelopmental Outcomes in the Adolescent Brain Cognitive Development (ABCD) Study.Children (Basel, Switzerland) · 2022Article
- Neurodevelopmental Profiles in Adolescence: Leveraging Data From the Landmark Adolescent Brain Cognitive Development Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Stress and adolescence: vulnerability and opportunity during a sensitive window of development.Current opinion in psychology · 2022Review
- Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®.Frontiers in psychiatry · 2022Article
- Identifying profiles of brain structure and associations with current and future psychopathology in youth.Developmental cognitive neuroscience · 2021Article
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Abstract
backgroundRegardless of the precise mechanism, all neurodevelopmental models of risk assume that, at the population level, there exist subgroups of individuals that share similar patterns of neural function and development-and that these subgroups somehow relate to psychiatric risk. However, the existence of multiple neurodevelopmental subgroups at the population level has not been assessed previously.
methodsIn the current study, cross-validated latent profile analysis was used to test for the presence of empirically derived, brain-based developmental subgroups using functional magnetic resonance imaging data from 6758 individuals (49.4% female; mean age = 9.94 years) in the Adolescent Brain and Cognitive Development (ABCD) study wave 1 release. Data were randomly split into training and testing samples.
resultsAnalyses in the training sample (n = 3379) identified a seven-profile solution (entropy = 0.880) that was replicated in the held-out testing data (n = 3379, entropy = 0.890). Identified subgroups included a moderate group (66.8%), high reward (4.3%) and low reward (4.0%) groups, high inhibition (9.8%) and low inhibition (6.7%) groups, and high emotion regulation (4.0%) and low emotion regulation (4.3%) groups. Relative to the moderate group, other subgroups were characterized by more males (χ
conclusionsThese data demonstrate the existence of multiple, distinct neurodevelopmental subgroups at the population level. They indicate that these empirically derived, brain-based developmental profiles relate to differences in clinical features, even at a young age, and prior to the peak period of risk for the development of psychopathology.
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