Evidence map›Paper›PMID 33705868›Full record

ArticleBrain, behavior, and immunity2021

Vulnerability to inflammation-related depressive symptoms: Moderation by stress in women with breast cancer.

Andrew W Manigault, Kate R Kuhlman, Michael R Irwin, Steve W Cole, Patricia A Ganz, Catherine M Crespi, Julienne E Bower

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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  12. Influencing factors of depressive symptoms in patients with malignant tumour.The Journal of international medical research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Andrew W ManigaultDepartment of Psychology, UCLA, Los Angeles, CA, United States. Electronic address: amanigault@psych.ucla.edu.
Kate R KuhlmanDepartment of Psychological Science, UCI, Irvine, CA, United States; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, United States.
Michael R IrwinDepartment of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, United States.
Steve W ColeCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, United States; David Geffen School of Medicine, UCLA, Los Angeles, CA, United States.
Patricia A GanzDavid Geffen School of Medicine, UCLA, Los Angeles, CA, United States; Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, United States.
Catherine M CrespiDepartment of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, United States.
Julienne E BowerDepartment of Psychology, UCLA, Los Angeles, CA, United States; Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, United States.
Neurobehavioral Systems · USUCLA Health · USUniversity of California, Los Angeles · USUniversity of California, Irvine · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Biobehavioral predictors of fatigue in newly-diagnosed breast cancer patientsR01CA160427 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E · 2012 to 2016
$3.2M
Behavioral and inflammatory responses to stress: Implications for depression in youth exposed to adversityK08MH112773 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUHLMAN, KATE RYAN · 2017 to 2021
$862k
NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA160427NIMH NIH HHS K08 MH112773NIMH NIH HHS T32 MH015750
6 · The paper itself

Abstract

backgroundStress precipitates depression and may do so in part by increasing susceptibility to inflammation-induced depressive symptoms. However, this has not been examined among individuals facing a major life stressor. Accordingly, the present study tested the moderating role of stress on the longitudinal association between inflammation and depressive symptoms among women with breast cancer.

methodsWomen recently diagnosed with early-stage breast cancer (N = 187) were enrolled before starting adjuvant/neoadjuvant treatment. Blood draws and self-reported depressive symptoms were collected pre-treatment, post-treatment, and at 6, 12, and 18-month post-treatment follow ups. C-reactive protein (CRP) was used to index inflammation. Measures of psychological stress, including cancer-related stress, general stress perceptions, and childhood stress, were administered pre-treatment.

resultsStress moderated the association between CRP and depressive symptoms, such that higher levels of CRP were associated with elevated depressive symptoms only among women who reported high cancer-related stress (β = 0.080, p = .002) and perceived stress (β = 0.053, p = .044); childhood stress effects were non-significant. Moreover, elevated CRP was associated with increased odds of exhibiting clinically significant depressive symptoms (OR = 1.64, p < .001) among women who reported high cancer-related stress. Results were independent of age, BMI, race and cancer-related covariates.

conclusionsStress was found to heighten sensitivity to inflammation-associated depressive symptoms over a 2-year period, with notably stronger effects for subjective stress responses to a concurrent life event. Individuals who are most distressed following a major life event may exhibit the greatest risk for inflammation-induced depression.

Indexed as

Breast NeoplasmsDepressionC-Reactive ProteinFemaleHumansInflammationStress, PsychologicalC-Reactive ProteinBreast cancerCRPDepressionInflammationStress

Identifiers

PMID33705868
PMCPMC8058308
OpenAlexW3135272272

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.