Evidence map›Paper›PMID 33705806›Full record

ArticleBiological psychology2021

Disinhibition of right inferior frontal gyrus underlies alpha asymmetry in women with low testosterone.

Justin Riddle, David R Rubinow, Susan Girdler, Flavio Frohlich

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Justin RiddleDepartment of Psychiatry, University of North Carolina at Chapel Hill, 304 MacNider Hall, 101 Manning Drive, Chapel Hill, NC, 27599, USA; Center for Women's Mood Disorders, University of North Carolina at Chapel Hill, Neurosciences Hospital, 101 Manning Drive, Chapel Hill, NC, 27599, USA; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, 6201 Mary Ellen Jones Building, 116 Manning Drive, Chapel Hill, NC, 27599, USA. Electronic address: justin_riddle@med.unc.edu.
David R RubinowDepartment of Psychiatry, University of North Carolina at Chapel Hill, 304 MacNider Hall, 101 Manning Drive, Chapel Hill, NC, 27599, USA; Center for Women's Mood Disorders, University of North Carolina at Chapel Hill, Neurosciences Hospital, 101 Manning Drive, Chapel Hill, NC, 27599, USA. Electronic address: david_rubinow@med.unc.edu.
Susan GirdlerDepartment of Psychiatry, University of North Carolina at Chapel Hill, 304 MacNider Hall, 101 Manning Drive, Chapel Hill, NC, 27599, USA; Center for Women's Mood Disorders, University of North Carolina at Chapel Hill, Neurosciences Hospital, 101 Manning Drive, Chapel Hill, NC, 27599, USA. Electronic address: susan_girdler@med.unc.edu.
Flavio FrohlichDepartment of Psychiatry, University of North Carolina at Chapel Hill, 304 MacNider Hall, 101 Manning Drive, Chapel Hill, NC, 27599, USA; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, 6201 Mary Ellen Jones Building, 116 Manning Drive, Chapel Hill, NC, 27599, USA; Department of Neurology, University of North Carolina at Chapel Hill, 170 Manning Drive, Chapel Hill, NC, 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 5200 Medical Biomolecular Research Building, 111 Mason Farm Road, Chapel Hill, NC, 27599, USA; Department of Biomedical Engineering, University of North Carolina at Chapel Hill, 10010 Mary Ellen Jones, 116 Manning Drive, Chapel Hill, NC, 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, 116 Manning Drive, Chapel Hill, NC, 27599, USA. Electronic address: flavio_frohlich@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Rational Optimization of tACS for Targeting Thalamo-Cortical OscillationsR01MH111889 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2016 to 2019
$2.4M
Targeting Cortical Dynamics: Rational Design of Individualized Brain StimulationR01MH101547 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FROHLICH, FLAVIO · 2013 to 2017
$2.2M
NIMH NIH HHS R01 MH101547NIMH NIH HHS R01 MH111889
6 · The paper itself

Abstract

Asymmetrical expression of alpha oscillations in the frontal cortex, increased left relative to right, is a phenotype associated with increased behavioral inhibition and mood-related psychiatric illnesses. However, investigations of frontal alpha asymmetry in mood-disorders have yielded inconsistent findings. A better understanding of factors that contribute to individual differences is required to establish a useful biomarker for the diagnosis and treatment of mood and stress related disorders. A novel factor is hormone concentration, as steroid hormones play a prominent role in regulating mood and stress. To investigate this question, concentrations of testosterone and estradiol were sampled. Multiple linear regression revealed that low levels of testosterone correlated with greater frontal alpha asymmetry in women. Source localization found that frontal asymmetry was driven by decreased alpha power in right inferior frontal gyrus that correlated with increased behavioral inhibition in women. Together, these findings might explain inconsistencies in previous investigation on frontal alpha asymmetry.

Indexed as

Alpha RhythmElectroencephalographyFemaleFrontal LobeFunctional LateralityHumansPrefrontal CortexTestosteroneTestosteroneAlpha asymmetryBehavioral inhibitionEEGEstradiolSource localizationTestosterone

Identifiers

PMID33705806
PMCPMC8113111
OpenAlexW3134021257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.