Evidence map›Paper›PMID 33705517›Full record

ReviewPathogens and disease2021

Rickettsia-host interaction: strategies of intracytosolic host colonization.

Oliver H Voss, M Sayeedur Rahman

Open access · hybridAbstract readReview
In one paragraph

Review in Pathogens and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. PathogenicJournal of bacteriology · 2024
    Review
  10. Metabolism and physiology of pathogenic bacterial obligate intracellular parasites.Frontiers in cellular and infection microbiology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Editorial: New insights on the transmission and pathogenicity of rickettsiae.Frontiers in cellular and infection microbiology · 2023
    Article
  16. Lock and Key: WhyPathogens (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Oliver H VossDepartment of Microbiology and Immunology, University of Maryland School of Medicine, HSF2, room 416, 20 Penn St, Baltimore, MD 21201, USA.
M Sayeedur RahmanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, HSF2, room 416, 20 Penn St, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · US

Funding

MURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSIONR01AI017828 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAHMAN, MOHAMMED SAYEEDUR · 1985 to 2022
$10.2M
Rickettsia-host interface and multiple paths to invasionR01AI126853 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Mohammed Sayeedur Rahman, Oliver Voss · 2016 to 2026
$6.9M
NIAID NIH HHS R01 AI017828NIAID NIH HHS R01 AI126853
6 · The paper itself

Abstract

Bacterial infection is a highly complex biological process involving a dynamic interaction between the invading microorganism and the host. Specifically, intracellular pathogens seize control over the host cellular processes including membrane dynamics, actin cytoskeleton, phosphoinositide metabolism, intracellular trafficking and immune defense mechanisms to promote their host colonization. To accomplish such challenging tasks, virulent bacteria deploy unique species-specific secreted effectors to evade and/or subvert cellular defense surveillance mechanisms to establish a replication niche. However, despite superficially similar infection strategies, diverse Rickettsia species utilize different effector repertoires to promote host colonization. This review will discuss our current understandings on how different Rickettsia species deploy their effector arsenal to manipulate host cellular processes to promote their intracytosolic life within the mammalian host.

Indexed as

Host-Pathogen InteractionsActin CytoskeletonAnimalsArthropod VectorsHost SpecificityHumansMetabolic Networks and PathwaysMitesPhosphatidylinositolsPhthirapteraPhylogenyRickettsiaRickettsia InfectionsSiphonapteraSpecies SpecificityTicksPhosphatidylinositolsbacterial adherence and engulfmentbacterial effector moleculeshost defensesintracellular traffickingphagosomal escapephosphoinositide metabolismRickettsia-host interactionspotted fever grouptransition grouptyphus group

Identifiers

PMID33705517
PMCPMC8023194
OpenAlexW3135213063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.