Article in PLoS pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
20 authors at 4 institutions in 1 country.
Forrest C WalkerDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0003-4503-8734
Ebrahim HassanDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0001-7870-9755
Stefan T PetersonDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Rachel RodgersDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0001-7787-0491
Lawrence A SchrieferDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0001-6865-8683
Cassandra E ThompsonDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0001-6273-8113
Yuhao LiDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0003-2413-0937
Gowri KalugotlaDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0002-0777-8275
Carla Blum-JohnstonDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0003-0540-9975
Dylan LawrenceDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0001-6919-8308
Broc T McCuneDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0002-8342-5316
Vincent R GrazianoDepartments of Laboratory Medicine & Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America.ORCID 0000-0003-1046-9753
Larissa LushniakDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0001-8970-989X
Sanghyun LeeDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0002-0736-1648
Alexa N RothDepartment of Molecular Genetics & Microbiology, Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.
Stephanie M KarstDepartment of Molecular Genetics & Microbiology, Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.ORCID 0000-0003-0406-4637
Timothy J NiceDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, United States of America.ORCID 0000-0002-4471-7666
Jonathan J MinerDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Craig B WilenDepartments of Laboratory Medicine & Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America.ORCID 0000-0003-2495-9403
Megan T BaldridgeDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0002-7030-6131
Washington University in St. Louis · USUniversity of Florida · USYale University · USOregon Health & Science University · US
Funding
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
Training Program in Cellular and Molecular BiologyT32GM139774 · NIGMS · WASHINGTON UNIVERSITY · PI HEATHER L TRUE-KROB · 2021 to 2026
$6.7M
Mechanisms of STING-associated immunodeficiencyR01AI143982 · NIAID · WASHINGTON UNIVERSITY · PI Jonathan J Miner · 2019 to 2026
$4.6M
The role of tuft cells in norovirus pathogenesisR01AI148467 · NIAID · YALE UNIVERSITY · PI Craig Brian Wilen · 2020 to 2026
$3.9M
Role of CD300 Family in Norovirus Tropism, Persistence, and ImmunityR01AI127552 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T, FREMONT, DAVED H. · 2017 to 2021
$3.5M
Suppression of Enteric Norovirus Infection by Microbiota-Regulated Bile AcidsR01AI141478 · NIAID · UNIVERSITY OF FLORIDA · PI KARST, STEPHANIE M · 2019 to 2023
$2.7M
Norovirus regulation via bacterial modulation of interferon-lambdaR01AI139314 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T · 2019 to 2023
$2.0M
Role of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940k
DEFINING THE IN VIVO ROLE OF DAP1 IN AUTOPHAGY AND COLITISF31CA177194 · NCI · WASHINGTON UNIVERSITY · PI MCCUNE, BROC TAYLOR · 2013 to 2015
Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary potential of this enteric virus. In animals lacking type I IFN signaling, the nonlethal MNoV strain CR6 rapidly acquired enhanced virulence via conversion of a single nucleotide. This nucleotide change resulted in amino acid substitution F514I in the viral capsid, which led to >10,000-fold higher replication in systemic organs including the brain. Pathogenicity was mediated by enhanced recruitment and infection of intestinal myeloid cells and increased extraintestinal dissemination of virus. Interestingly, the trade-off for this mutation was reduced fitness in an IFN-competent host, in which CR6 bearing F514I exhibited decreased intestinal replication and shedding. In an immunodeficient context, a spontaneous amino acid change can thus convert a relatively avirulent viral strain into a lethal pathogen.
Indexed as
AnimalsCaliciviridae InfectionsCapsid ProteinsGenetic FitnessImmunity, InnateMiceNorovirusPolymorphism, Single NucleotideVirulenceVirus ReplicationCapsid Proteins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid. · full record | OpenQuestion