ArticlePloS one2021
Association between continuity of care and subsequent diagnosis of multimorbidity in Ontario, Canada from 2001-2015: A retrospective cohort study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- The impact of adverse childhood experiences on multimorbidity: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Midwife continuity of care models versus other models of care for childbearing women.The Cochrane database of systematic reviews · 2024Pooled it
- Determinants of central obesity in children and adolescents and associated complications in South Africa: a systematic review.Frontiers in public health · 2024Pooled it
- Primary care continuity and breast cancer survival: a retrospective cohort study.Cancer causes & control : CCC · 2026Article
- Impact of grassroots development of interprofessional team-based practices: Retrospective matched cohort study using ICES data.Canadian family physician Medecin de famille canadien · 2026Article
- Emergency Department Visits, Hospital Admissions, and Wait Times for Patients With Urologic Conditions.JAMA network open · 2026Article
- Article
- Effect of Continuity of Care on Emergency Care and Hospital Admissions Among Patients Receiving Home-Based Care: A Population-Based Cohort Study.Annals of family medicine · 2026Article
- Determinants of the onset and development of multimorbidity in different subpopulations of older Chinese adults: insights from the China Health and Retirement Longitudinal Study.Annals of medicine · 2025Article
- Impact of the Basic Mandatory Health Insurance "AMO-Tadamon" on Continuity of Care Among Breast Cancer Patients Treated at the Oncology Center of the CHU Mohammed VI in Tangier: A Mixed Longitudinal Cohort Study.Cancer management and research · 2025Article
- Article
- Transformation to a patient-centred medical home led and delivered by an urban Aboriginal and Torres Strait Islander community, and association with engagement and quality-of-care: quantitative findings from a pilot study.BMC health services research · 2023Article
- The associations of continuity of care with inpatient, outpatient, and total medical care costs among older adults with urinary incontinence.BMC health services research · 2023Article
- Continuity of care in diverse ethnic groups: a general practice record study in England.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Continuity of care in primary healthcare settings among patients with chronic diseases in Saudi Arabia.SAGE open medicine · 2023Article
- The association between multimorbidity and mobility disability-free life expectancy in adults aged 85 years and over: A modelling study in the Newcastle 85+ cohort.PLoS medicine · 2022Article
- Relational Continuity of Chronic Patients with Primary and Secondary Care Doctors: A Study of Public Healthcare Networks of Six Latin American Countries.International journal of environmental research and public health · 2022Article
- Continuity of GP care for patients with dementia: impact on prescribing and the health of patients.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Article
- Typology of virtual primary care in Canada: Making the implications clear.Canadian family physician Medecin de famille canadienArticle
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContinuity of care is a well-recognized principle of the primary care discipline owing to its medical, interpersonal, and cost-saving benefits. Relationship continuity or the ongoing therapeutic relationship between a patient and their physician is a particularly desirable goal, but its role in preventing the accumulation of chronic conditions diagnoses in individuals is unknown. The objective of this study was to investigate the effect of continuity of care with physicians on the rate of incident multimorbidity diagnoses in patients with existing conditions.
methodsThis was a population-based, retrospective cohort study from 2001 to 2015 that focused on patients aged 18 to 105 years with at least one chronic condition (n = 166,665). Our primary exposure was relationship continuity of care with general practitioners and specialists measured using the Bice-Boxerman Continuity of Care Index (COCI). COCI was specified as a time-dependent exposure prior to the observation period. Our outcomes of interest were the time to diagnosis of a second, third, and fourth chronic condition estimated using cause-specific hazard regressions accounting for death as a competing risk.
findingsWe observed that patients with a single chronic condition and high continuity of care (>0.50) were diagnosed with a second chronic condition or multimorbidity at an 8% lower rate compared to individuals with low continuity (cause-specific hazard ratio (HR) 0.92 (95% Confidence Interval 0.90-0.93; p<0.0001) after adjusting for age, sex, income, place of residence, primary care enrolment, and the annual number of physician visits. Continuity remained protective as the degree of multimorbidity increased. Among patients with two conditions, the risk of diagnosis of a third chronic condition was also 8% lower for individuals with high continuity (HR 0.92; CI 0.90-0.94; p<0.0001). Patients with three conditions and high continuity had a 9% lower risk of diagnosis with a fourth condition (HR 0.91; CI 0.89-0.93; p<0.0001).
conclusionsContinuity of care is a potentially modifiable health system factor that reduces the rate at which diagnoses of chronic conditions are made over time in patients with multimorbidity. Additional research is needed to explain the underlying mechanisms through which continuity is related to a protective effect and the clinical sequalae.
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