SynthesisHuman brain mapping2021
Gray matter structures associated with neuroticism: A meta-analysis of whole-brain voxel-based morphometry studies.
Synthesis in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 8 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Comparative meta-analysis of task-related functional brain abnormalities in nonsuicidal self-injury and suicide attempt.Frontiers in psychiatry · 2026Pooled it
- Common and distinct patterns of brain activity alterations during inhibitory control in depression and psychostimulant users: a comparative meta-analysis of task-based fMRI studies.Psychological medicine · 2025Pooled it
- Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Pathological fear, anxiety and negative affect exhibit distinct neurostructural signatures: evidence from psychiatric neuroimaging meta-analysis.Translational psychiatry · 2022Pooled it
- Gray and white matter abnormality in patients with T2DM-related cognitive dysfunction: a systemic review and meta-analysis.Nutrition & diabetes · 2022Pooled it
- Gray Matter Volume Abnormality in Chronic Pain Patients With Depressive Symptoms: A Systemic Review and Meta-Analysis of Voxel-Based Morphometry Studies.Frontiers in neuroscience · 2022Pooled it
- Gray matter structures associated with neuroticism: A meta-analysis of whole-brain voxel-based morphometry studies.Human brain mapping · 2021Pooled it
- Common and specific patterns of functional and structural brain alterations in schizophrenia and bipolar disorder: a multimodal voxel-based meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Trait-relevant movies amplify neuroticism-associated brain responses.Communications psychology · 2026Article
- The mediating effect of neuroticism on the association between brain signal variability in the prefrontal cortex and depression among healthy individuals.Brain imaging and behavior · 2026Article
- Exploring the shared genetic architecture and causal relationship between childhood maltreatment and psychiatric disorders.Molecular psychiatry · 2026Article
- The functional neurobiology of dispositions towards negative emotions.Nature communications · 2026Article
- Age-varying distinct neuroanatomy in young children with autism spectrum disorder and fragile X syndrome.Molecular psychiatry · 2026Article
- Personality and cortical architecture in premenstrual dysphoric disorder.Archives of women's mental health · 2026Article
- 7-Tesla ultra-high field MRI of the parahippocampal cortex reveals evidence of common neurobiological mechanisms of major depressive disorder and neurotic personality traits.Translational psychiatry · 2025Article
- The functional neurobiology of negative affective traits across regions, networks, signatures, and a machine learning multiverse.bioRxiv : the preprint server for biology · 2025Article
- Network-based mapping and neurotransmitter architecture of gray matter correlates of neuroticism.Frontiers in systems neuroscience · 2025Article
- Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Identifying tripartite relationship among cortical thickness, neuroticism, and mood and anxiety disorders.Scientific reports · 2024Article
- Sex differences in the relationship between brain gray matter volume and psychological resilience in late adolescence.European child & adolescent psychiatry · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroticism is major higher-order personality trait and has been robustly associated with mental and physical health outcomes. Although a growing body of studies have identified neurostructural markers of neuroticism, the results remained highly inconsistent. To characterize robust associations between neuroticism and variations in gray matter (GM) structures, the present meta-analysis investigated the concurrence across voxel-based morphometry (VBM) studies using the anisotropic effect size signed differential mapping (AES-SDM). A total of 13 studies comprising 2,278 healthy subjects (1,275 females, 29.20 ± 14.17 years old) were included. Our analysis revealed that neuroticism was consistently associated with the GM structure of a cluster spanning the bilateral dorsal anterior cingulate cortex and extending to the adjacent medial prefrontal cortex (dACC/mPFC). Meta-regression analyses indicated that the neuroticism-GM associations were not confounded by age and gender. Overall, our study is the first whole-brain meta-analysis exploring the brain structural correlates of neuroticism, and the findings may have implications for the intervention of high-neuroticism individuals, who are at risk of mental disorders, by targeting the dACC/mPFC.
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