ArticleAnnals of neurology2021
Electroencephalographic Abnormalities are Common in COVID-19 and are Associated with Outcomes.
Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Parallel electrophysiological abnormalities due to COVID-19 infection and to Alzheimer's disease and related dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Imaging Markers of Neurologic Damage in COVID-19: A Systematic Review.Current medicinal chemistry · 2023Pooled it
- Non-Invasive Multimodal Neuromonitoring in Non-Critically Ill Hospitalized Adult Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2022Pooled it
- Review
- Strategies for Safer Cefepime Use to Prevent Neurotoxicity Using the Electronic Health Record.Critical care explorations · 2026Article
- Neuropsychiatric Manifestations of Long COVID-19: A Narrative Review of Clinical Aspects and Therapeutic Approaches.Life (Basel, Switzerland) · 2025Review
- Astroglia's role in synchronized spontaneous neuronal activity: from physiology to pathology.Frontiers in cellular neuroscience · 2025Review
- Article
- Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis.Nature microbiology · 2024Article
- Brain on Fire: How Brain Infection and Neuroinflammation Drive Worldwide Epilepsy Burden.Epilepsy currents · 2024Review
- New Onset Seizures in Hospitalized COVID-19 Patients; A Systematic Review and Meta-Analysis.The Neurohospitalist · 2024Article
- causalCmprsk: An R package for nonparametric and Cox-based estimation of average treatment effects in competing risks data.Computer methods and programs in biomedicine · 2023Article
- [Subtle and subclinical neurological findings in patients with SARS-CoV-2].Revista medica del Instituto Mexicano del Seguro Social · 2023Observational
- Effects of COVID-19 on cognition and brain health.Trends in cognitive sciences · 2023Review
- Automated detection of immune effector cell-associated neurotoxicity syndrome via quantitative EEG.Annals of clinical and translational neurology · 2023Observational
- Effects of epileptiform activity on discharge outcome in critically ill patients in the USA: a retrospective cross-sectional study.The Lancet. Digital health · 2023Article
- Association of Epileptiform Activity With Outcomes in Toxic-Metabolic Encephalopathy.Critical care explorations · 2023Article
- SARS-CoV-2 alters neural synchronies in the brain with more severe effects in younger individuals.Scientific reports · 2023Article
- Neurological Manifestations of Non-Severe COVID-19-A Multidirectional Approach.Brain sciences · 2023Article
- Possible post-COVID epilepsy: A review of epilepsy monitoring unit admissions during the two years of COVID-19 pandemic.Epilepsy & behavior reports · 2023Article
Corrections and comments
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Authors and funding
25 authors at 9 institutions in 2 countries.
Funding
Abstract
objectiveThe aim was to determine the prevalence and risk factors for electrographic seizures and other electroencephalographic (EEG) patterns in patients with Coronavirus disease 2019 (COVID-19) undergoing clinically indicated continuous electroencephalogram (cEEG) monitoring and to assess whether EEG findings are associated with outcomes.
methodsWe identified 197 patients with COVID-19 referred for cEEG at 9 participating centers. Medical records and EEG reports were reviewed retrospectively to determine the incidence of and clinical risk factors for seizures and other epileptiform patterns. Multivariate Cox proportional hazards analysis assessed the relationship between EEG patterns and clinical outcomes.
resultsElectrographic seizures were detected in 19 (9.6%) patients, including nonconvulsive status epilepticus (NCSE) in 11 (5.6%). Epileptiform abnormalities (either ictal or interictal) were present in 96 (48.7%). Preceding clinical seizures during hospitalization were associated with both electrographic seizures (36.4% in those with vs 8.1% in those without prior clinical seizures, odds ratio [OR] 6.51, p = 0.01) and NCSE (27.3% vs 4.3%, OR 8.34, p = 0.01). A pre-existing intracranial lesion on neuroimaging was associated with NCSE (14.3% vs 3.7%; OR 4.33, p = 0.02). In multivariate analysis of outcomes, electrographic seizures were an independent predictor of in-hospital mortality (hazard ratio [HR] 4.07 [1.44-11.51], p < 0.01). In competing risks analysis, hospital length of stay increased in the presence of NCSE (30 day proportion discharged with vs without NCSE: HR 0.21 [0.03-0.33] vs 0.43 [0.36-0.49]).
interpretationThis multicenter retrospective cohort study demonstrates that seizures and other epileptiform abnormalities are common in patients with COVID-19 undergoing clinically indicated cEEG and are associated with adverse clinical outcomes. ANN NEUROL 2021;89:872-883.
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Registered trials
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