ArticleEquine veterinary journal2022
Active equine parvovirus-hepatitis infection is most frequently detected in Austrian horses of advanced age.
Article in Equine veterinary journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Molecular prevalence of equine parvovirus hepatitis in healthy horses from the Northern region of the state of Rio Grande do Sul, Brazil.Veterinary research communications · 2026Article
- Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia.Viruses · 2024Article
- Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses.Veterinary pathology · 2024Article
- Article
- Prevalence of equine parvovirus-hepatitis in healthy broodmares in Ontario, Canada.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Prevalence and pathology of equine parvovirus-hepatitis in racehorses from New York racetracks.Virology journal · 2022Article
- Nasal transmission of equine parvovirus hepatitis.Journal of veterinary internal medicine · 2022Article
- Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update.Animals : an open access journal from MDPI · 2022Review
- Active equine parvovirus-hepatitis infection is most frequently detected in Austrian horses of advanced age.Equine veterinary journal · 2022Article
- Genetic characterization of three recently discovered parvoviruses circulating in equines in China.Frontiers in veterinary science · 2022Article
- Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea.Veterinary sciences · 2021Article
- First Detection and Genetic Characterization of New Equine Parvovirus Species Circulating among Horses in Korea.Veterinary sciences · 2021Article
- Small but mighty: old and new parvoviruses of veterinary significance.Virology journal · 2021Review
- Investigation of Three Newly Identified Equine Parvoviruses in Blood and Nasal Fluid Samples of Clinically Healthy Horses and Horses with Acute Onset of Respiratory Disease.Animals : an open access journal from MDPI · 2021Article
- Article
- Equine parvovirus hepatitis.Equine veterinary journal · 2021Review
- New Parvoviruses and Picornavirus in Tissues and Feces of Foals with Interstitial Pneumonia.Viruses · 2021Article
- Equine Parvovirus-Hepatitis Screening in Horses and Donkeys with Histopathologic Liver Abnormalities.Viruses · 2021Article
- Clinical Course of Infection and Cross-Species Detection of Equine Parvovirus-Hepatitis.Viruses · 2021Article
- Circovirus in Blood of a Febrile Horse with Hepatitis.Viruses · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEquine parvovirus-hepatitis (EqPV-H) research is in its infancy. Information regarding prevalence, geographical distribution, genetic diversity, pathogenesis and risk factors enhances understanding of this potentially fatal infection.
objectivesDetermining the prevalence of EqPV-H in Austrian equids. Investigating factors increasing probability of infection, liver-associated biochemistry parameters, concurrent equine hepacivirus (EqHV) infection and phylogenetic analysis of Austrian EqPV-H variants. STUDY
designCross-sectional study.
methodsSera from 259 horses and 13 donkeys in Austria were analysed for anti-EqPV-H VP1-specific antibodies by luciferase immunoprecipitation system (LIPS) and EqPV-H DNA by nested polymerase chain reaction (PCR). Associations between infection status, sex and age were described. Glutamate dehydrogenase (GLDH), gamma-glutamyl transferase (GGT), bile acids and albumin concentrations were compared between horses with active infection and PCR-negative horses. PCR targeting partial EqPV-H NS1 was performed and phylogenetic analysis of Austrian EqPV-H variants was conducted. Complete coding sequences (CDS) of four Austrian variants were determined by next-generation sequencing (NGS) and compared with published sequences.
resultsHorses' EqPV-H seroprevalence was 30.1% and DNA prevalence was 8.9%. One horse was co-infected with EqHV. Significantly, higher probability of active EqPV-H infection was identified in 16- to 31-year-old horses, compared with 1- to 8-year-old horses (P = 0.002; OR = 8.19; 95% CI = 1.79 to 37.50) and 9- to 15-year-old horses (P = 0.03; OR = 2.96; 95% CI = 1.08 to 8.17). Liver-associated plasma parameters were not significantly different between horses with active infection and controls. Austrian EqPV-H variants revealed high similarity to sequences worldwide. No evidence of EqPV-H was detected in donkeys. MAIN LIMITATIONS: Equids' inclusion depended upon owner consent. There was only one sampling point per animal and the sample of donkeys was small.
conclusionsEqPV-H antibodies and DNA are frequently detected in Austrian horses, without associated hepatitis in horses with active infection. The risk of active EqPV-H infection increases with increasing age. Phylogenetic evidence supports close relation of EqPV-H variants globally, including Austrian variants.
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