Evidence map›Paper›PMID 33704793›Full record

ArticleMedical physics2021

Evaluation of a variable-aperture full-ring SPECT system using large-area pixelated CZT modules: A simulation study for brain SPECT applications.

Yoonsuk Huh, Jaewon Yang, Odera U Dim, Yonggang Cui, Weijie Tao, Qiu Huang, Grant T Gullberg, Youngho Seo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Individual and Simultaneous Imaging ofIEEE transactions on radiation and plasma medical sciences · 2025
    Article
  2. Article
  3. EANM perspectives for CZT SPECT in brain applications.European journal of nuclear medicine and molecular imaging · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Yoonsuk HuhDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Jaewon YangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Odera U DimDepartment of Nonproliferation and National Security, Brookhaven National Laboratory, Upton, NY, USA.
Yonggang CuiDepartment of Nonproliferation and National Security, Brookhaven National Laboratory, Upton, NY, USA.
Weijie TaoDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Qiu HuangDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Grant T GullbergDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Brookhaven National Laboratory · USShanghai Jiao Tong University · CNUniversity of California System · USLawrence Berkeley National Laboratory · USUniversity of California, San Francisco · US

Funding

Energy-independent single photon molecular imaging technologyR01EB026331 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CUI, YONGGANG, SEO, YOUNGHO · 2018 to 2022
$2.6M
Dynamic cardiac SPECTR01HL135490 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GULLBERG, GRANT T, SEO, YOUNGHO · 2017 to 2020
$2.4M
Energy-Independent Single Photon Molecular Imaging TechnologyR01EB012965 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CUI, YONGGANG, SEO, YOUNGHO · 2011 to 2014
$2.2M
Restless Legs risk in the biracial East Baltimore cohortR03AG026331 · NIA · JOHNS HOPKINS UNIVERSITY · PI LEE, HOCHANG B · 2005 to 2006
$137k
National Institute of Biomedical Imaging and Bioengineering grants R01EB012965National Institute of Biomedical Imaging and Bioengineering grants R01EB026331NHLBI NIH HHS R01 HL135490NHLBI NIH HHS R01HL135490NIBIB NIH HHS R01 EB012965NIBIB NIH HHS R01 EB026331
6 · The paper itself

Abstract

purposeSingle photon emission computed tomography (SPECT) scanners using cadmium zinc telluride (CZT) offer compact, lightweight, and improved imaging capability over conventional NaI(Tl)-based SPECT scanners. The main purpose in this study is to propose a full-ring SPECT system design with eight large-area CZT detectors that can be used for a broad spectrum of SPECT radiopharmaceuticals and demonstrate the performance of our system in comparison to the reference conventional NaI(Tl)-based two-head Anger cameras.

methodsA newly designed full-ring SPECT system is composed of eight large-area CZT cameras (128 mm × 179.2 mm effective area) that can be independently swiveled around their own axes of rotation independently and can have radial motion for varying aperture sizes that can be adapted to different sizes of imaging volume. Extended projection data were generated by conjoining projections of two adjacent detectors to overcome the limited field-of-view (FOV) by each CZT camera. Using Monte Carlo simulations, we evaluated this new system design with digital phantoms including a Derenzo hot rod phantom and a Zubal brain phantom. Comparison of performance metrics such as spatial resolution, sensitivity, contrast-to-noise ratio (CNR), and contrast-recovery ratio was made between our design and conventional SPECT scanners having different pixel sizes and radii of rotation (one clinically well-known type and two arbitrary types matched to our proposed CZT-SPECT geometries).

resultsThe proposed scanner could result in up to about three times faster in acquisition time over conventional scan time at same acquisition time per step. The spatial resolution improvement, or deterioration, of our proposed scanner compared to the clinical-type scanner was dependent upon the location of the point source. However, there were overall performance improvements over the three different setups of the conventional scanner particularly in volume sensitivity (approximately up to 1.7 times). Overall, we successfully reconstructed the phantom image for both

conclusionsWe proposed a variable-aperture full-ring SPECT system using combined pixelated CZT and energy-optimized parallel-hole collimator modules and evaluated the performance of this scanner using relevant digital phantoms and MC simulations. Our studies demonstrated the potential of our new full-ring CZT-SPECT design, showing reduced acquisition time and improved sensitivity with acceptable CNR and spatial resolution.

Indexed as

CadmiumTelluriumBrainPhantoms, ImagingTomography, Emission-Computed, Single-PhotonZincCadmiumTelluriumZincbrain SPECTCZT detectorfull ringMonte Carlo simulationSPECT

Identifiers

PMID33704793
PMCPMC8141019
OpenAlexW3133744538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.