Evidence map›Paper›PMID 33704613›Full record

ArticleJournal of autism and developmental disorders2022

Trajectories of Symptom Severity in Children with Autism: Variability and Turning Points through the Transition to School.

Stelios Georgiades, Peter A Tait, Paul D McNicholas, Eric Duku, Lonnie Zwaigenbaum, Isabel M Smith, Teresa Bennett, Mayada Elsabbagh, Connor M Kerns, Pat Mirenda and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Overall prognosis of preschool autism spectrum disorder diagnoses.The Cochrane database of systematic reviews · 2022
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  16. Methodological challenges and opportunities when studying the course of autism.Autism : the international journal of research and practice · 2025
    Article
  17. Article
  18. Trajectories of autism symptom severity for boys and girls across childhood.Autism : the international journal of research and practice · 2025
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 2 countries.

Stelios GeorgiadesDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main St. W. - MIP Suite 201A, Hamilton, ON, L8S 4K1, Canada. georgis@mcmaster.ca.
Peter A TaitDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main St. W. - MIP Suite 201A, Hamilton, ON, L8S 4K1, Canada.
Paul D McNicholasDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main St. W. - MIP Suite 201A, Hamilton, ON, L8S 4K1, Canada.
Eric DukuDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main St. W. - MIP Suite 201A, Hamilton, ON, L8S 4K1, Canada.
Lonnie ZwaigenbaumUniversity of Alberta, Edmonton, Canada.
Isabel M SmithIWK Health Centre, Dalhousie University, Halifax, Canada.
Teresa BennettDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main St. W. - MIP Suite 201A, Hamilton, ON, L8S 4K1, Canada.
Mayada ElsabbaghMcGill University, Montreal, Canada.
Connor M KernsUniversity of British Columbia, Vancouver, Canada.
Pat MirendaUniversity of British Columbia, Vancouver, Canada.
Wendy J UngarUniversity of Toronto, The Hospital for Sick Children, Toronto, Canada.
Tracy VaillancourtUniversity of Ottawa, Ottawa, Canada.
Joanne VoldenUniversity of Alberta, Edmonton, Canada.
Charlotte WaddellSimon Fraser University, Burnaby, Canada.
Anat Zaidman-ZaitTel Aviv University, Tel Aviv, Israel.
Stephen GentlesDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main St. W. - MIP Suite 201A, Hamilton, ON, L8S 4K1, Canada.
Peter SzatmariCentre for Addition and Mental Health, Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, The Hospital for Sick Children, Toronto, Canada.
McMaster University · CAUniversity of Alberta · CAUniversity of British Columbia · CADalhousie University · CAHospital for Sick Children · CAMcGill University · CASimon Fraser University · CATel Aviv University · ILUniversity of Ottawa · CAUniversity of Toronto · CA

Funding

Canadian Institutes of Health Research (CA) FDN 143235Canadian Institutes of Health Research (CA) FDN 93621CIHR HDF-70333
6 · The paper itself

Abstract

This study examined the trajectories of autistic symptom severity in an inception cohort of 187 children with ASD assessed across four time points from diagnosis to age 10. Trajectory groups were derived using multivariate cluster analysis. A two trajectory/cluster solution was selected. Change in trajectory slopes revealed a turning point marked by plateauing in symptom reduction during the period of transition to school (age 6) for one of the two trajectories. Trajectories were labelled: Continuously Improving (27%) and Improving then Plateauing (73% of sample). Children in the two trajectories differed in levels of symptom severity, language, cognitive, and adaptive functioning skills. Study findings can inform the development of more personalized services for children with ASD transitioning into the school system.

Indexed as

Autism Spectrum DisorderAutistic DisorderChildHumansLanguageMultivariate AnalysisSchoolsAutism spectrum disorderChronogeneityTrajectoriesTurning points

Identifiers

PMID33704613
PMCPMC8732828
OpenAlexW3134367224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.