ArticleCellular and molecular neurobiology2022
Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy.
Article in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Photobiomodulation and sleep quality: systematic review and meta-analysis.Lasers in medical science · 2026Pooled it
- Transabdominal photobiomodulation applications: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Photobiomodulation in the aging brain: a systematic review from animal models to humans.GeroScience · 2024Pooled it
- Photobiomodulation improves depression symptoms: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2023Pooled it
- Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies.Frontiers in neuroscience · 2022Pooled it
- Lights for aging: Can photobiomodulation restore functionality in the cerebral networks of aged individuals?Neural regeneration research · 2026Article
- Transcranial Photobiomodulation Modulates Oxidative Stress Biomarkers and Complex IV Activity in Anhedonic-Like Behavior.Neurochemical research · 2026Article
- Targeting glymphatic-associated pathways for Alzheimer's disease: a review of non-invasive modulation strategies, mechanisms, and emerging evidence.Frontiers in immunology · 2026Review
- Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Seizure Frequency and Brain Metabolomics of Rats with Pilocarpine-Induced Seizures.Molecular neurobiology · 2025Article
- Safety of 810 nm photobiomodulation in the developing brain: no evidence of glial reactivity or pro-inflammatory cytokine expression in rats.Lasers in medical science · 2025Article
- Use of Mitochondrial Delayed Luminescence Measurements From Brain Tissue to Optimize Photobiomodulation Prarameters in Alzheimer's Disease Mice.Journal of biophotonics · 2025Article
- Photobiomodulation as a Hypothetical Strategy to Reverse Botulinum Toxin Effects: Exploring the Neuroregenerative Mechanisms and Translational Potential.Life (Basel, Switzerland) · 2025Review
- Effects of Photobiomodulation on Nervous System Disorders: A Narrative Review.Journal of lasers in medical sciences · 2025Review
- Electromagnetic Modulation of Cell Behavior: Unraveling the Positive Impacts in a Comprehensive Review.Annals of biomedical engineering · 2024Review
- Photobiomodulation for Neurodegenerative Diseases: A Scoping Review.International journal of molecular sciences · 2024Article
- Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends.Neurophotonics · 2024Review
- Effects of Cyfluthrin Exposure on Neurobehaviour, Hippocampal Tissue and Synaptic Plasticity in Wistar Rats.Toxics · 2023Article
- Photobiomodulation regulates adult neurogenesis in the hippocampus in a status epilepticus animal model.Scientific reports · 2022Article
- Multiple system atrophy.Nature reviews. Disease primers · 2022Review
- Photobiomodulation Improves the Inflammatory Response and Intracellular Signaling Proteins Linked to Vascular Function and Cell Survival in the Brain of Aged Rats.Molecular neurobiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidences have shown the therapeutic potential of transcranial photobiomodulation on traumatic brain injury and Alzheimer's disease. Despite the promising benefits in the brain, little is known about the laser's effects in the absence of pathological conditions. We submitted young (4 months old) and aged (20 months old) rats to transcranial low-level laser and evaluated their exploratory activity and habituation in open field, anxiety in elevated plus maze, spatial memory in Barnes maze, and aversive memory in a step-down inhibitory avoidance task. Additionally, the levels of a panel of inflammatory cytokines and chemokines were quantified in two different brain regions: the cerebral cortex and the hippocampus. Young and aged rats submitted to transcranial laser exhibited better cognitive performance in Barnes maze than did control rats. Transcranial laser therapy decreased cortical levels of GM-CSF, IL-10, MCP-1, LIX, and TNFα in young rats and IL-5 in aged rats. High levels of IL-6, IL-10, and TNF-alpha were found in the cerebral cortex of aged rats submitted to transcranial laser. In the hippocampus, a decrease in IP-10 and fractalkine levels was observed in the aged rats from the laser group when compared to the aged rats from the control group. Our data indicate that transcranial photobiomodulation improves spatial learning and memory and alters the neuroinflammatory profile of young and aged rats' brains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.