ArticleJournal of neurology2021
Cognitive and behavioral profile of progressive supranuclear palsy and its phenotypes.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The Cognitive Profile of Atypical Parkinsonism: A Meta-Analysis.Neuropsychology review · 2023Pooled it
- Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy.Movement disorders clinical practice · 2026Article
- Article
- Cognitive and behavioral disturbances in PSP and MSA: clinical features and imaging correlates.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Dementia in Progressive Supranuclear Palsy: A Narrative Review.Neurology and therapy · 2026Review
- Natural products proposed for the management of Huntington's disease (HD): a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Language impairment is associated with faster progression in progressive supranuclear palsy-Richardson syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy.Movement disorders clinical practice · 2025Article
- Differences in neuropsychological performance across clinical variants of progressive supranuclear palsy.Journal of the International Neuropsychological Society : JINS · 2025Article
- High rates of diagnostic discordance and co-pathology: Insights into PSP from the NACC dataset.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Rapid Cognitive Deterioration in Progressive Supranuclear Palsy: A 1-Year Follow-Up Study.Movement disorders clinical practice · 2025Article
- Pathomechanisms of neuropsychiatric disturbances in atypical parkinsonian disorders: a current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Domain-specific brain regions are associated with cognitive impairment in progressive supranuclear palsy.Neuroimage. Reports · 2025Article
- Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies.NPJ Parkinson's disease · 2024Article
- Predicting Disability in Progressive Supranuclear Palsy Using Bedside Frontal-Lobe Signs.Movement disorders clinical practice · 2024Article
- Investigating differences in young- and late-onset progressive supranuclear palsy.Journal of neurology · 2023Article
- Pathomechanisms of cognitive impairment in progressive supranuclear palsy.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Subjective cognitive complaints in patients with progressive supranuclear palsy.Frontiers in neurology · 2023Article
- The Assessment of Subregions in the Frontal Lobe May Be Feasible in the Differential Diagnosis of Progressive Supranuclear Palsy-Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA).Diagnostics (Basel, Switzerland) · 2022Article
- Social cognition in the FTLD spectrum: evidence from MRI.Journal of neurology · 2022Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAlthough several progressive supranuclear palsy (PSP) phenotypes have recently been described, studies identifying cognitive and neuropsychiatric differences between them are lacking.
methodsAn extensive battery of cognitive and behavioural assessments was administered to 63 PSP patients, 25 PD patients with similar sociodemographic characteristics, and 25 healthy controls. We analysed differences in phenomenology, frequency and severity of cognitive and neuropsychiatric symptoms between PSP, PD and HC, and between PSP subtypes.
resultsRegarding phenotypes, 64.6% met criteria for Richardson's syndrome (PSP-RS), 10.7% PSP with predominant Parkinsonism (PSP-P), 10.7% with PSP progressive gait freezing (PSP-PGF), and 10.7% PSP with predominant speech/language disorder (PSP-SL). Impairment was more severe in the PSP group than in the PD and HC groups regarding motor scores, cognitive testing and neuropsychiatric scales. Cognitive testing did not clearly differentiate between PSP phenotypes, but PSP-RS and PSP-SL appeared to have more cognitive impairment than PSP-PGF and PSP-P, mainly due to an increased impairment in frontal executive domains. Regarding neuropsychiatric disturbances, no specific behavior was more common in any of the PSP subtypes.
conclusionMotor deficits delineate the phenotypes included in currently accepted MDS-PSP criteria. Cognition and behavioural disturbances are common in PSP and allow us to distinguish this disorder from other neurological diseases, but they do not differentiate between PSP phenotypes.
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