SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2021
Association of serum 25(OH)Vit-D levels with risk of pediatric fractures: a systematic review and meta-analysis.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07143552 (A Prospective Case-Control Study of Vitamin D Status, Bone Metabolic Markers, and Overweight in Pediatric Low-Energy Fractures), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Case-Control Study of Vitamin D Status, Bone Metabolic Markers, and Overweight in Pediatric Low-Energy Fractures
Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Influence of vitamin D supplementation on bone mineral content, bone turnover markers, and fracture risk in South African schoolchildren: multicenter double-blind randomized placebo-controlled trial (ViDiKids).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Trial
- Vitamin D status and adiposity in children with low-energy fractures: a prospective case-control study.European journal of pediatrics · 2026Observational
- BMI, Vitamin D Status, and Biochemical Markers of Mineralization in Children with Low-Energy Fractures: A Prospective Case-Control Study.Children (Basel, Switzerland) · 2026Article
- Vitamin D and Health Outcomes: State-of-the-Art Review of Triangulated Evidence and Ongoing Controversies.Current nutrition reports · 2026Review
- Low Vitamin D Levels Are Associated With Longer Healing Times in Pediatric Fracture Patients.Journal of the Pediatric Orthopaedic Society of North America · 2026Article
- Proximal Tibial Epiphyseal Injury in a 14-Year-Old Asian Male With Vitamin D Deficiency as a Possible Cause: A Case Report.Case reports in orthopedics · 2026Article
- Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone as Functional Biomarkers of Bone Mass in Early Childhood.The Journal of nutrition · 2025Observational
- Vitamin D and pediatric bone health: Important information and considerations for the pediatric orthopaedic surgeon.Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- Potential Interaction betweenBiomedicines · 2024Article
- Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin DThe journal of physiological sciences : JPS · 2024Article
- Bone Health in Young Athletes: a Narrative Review of the Recent Literature.Current osteoporosis reports · 2023Review
- Low levels of serum vitamin C in children with limb fractures: a case-control study.Frontiers in pediatrics · 2023Article
- Vitamin D and Forearm Fractures in Children Preliminary Findings: Risk Factors and Correlation between Low-Energy and High-Energy Fractures.Children (Basel, Switzerland) · 2022Article
- Simultaneous determination of vitamin D metabolites 25(OH)DJournal of mass spectrometry and advances in the clinical lab · 2022Article
- Decreased cortical bone density and mechanical strength with associated elevated bone turnover markers at peri-pubertal peak height velocity: a cross-sectional and longitudinal cohort study of 396 girls with adolescent idiopathic scoliosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Prevalence of Vitamin D Deficiency in Children with Fractures: Before and during the COVID-19 Outbreak.International journal of clinical practice · 2022Article
- Association of serum 25OHD levels with risk of paediatric fractures.Journal of bone and mineral metabolism · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between the risk of fractures and suboptimal vitamin D (Vit-D) status remains controversial in children. This meta-analysis suggested that serum 25(OH)Vit-D levels were lower in pediatric cases with fractures. 25-hydroxyvitamin D (25(OH)Vit-D) levels less than 50 nmol/L were associated with increased fracture risk in children.
introductionThis study aimed to assess the association between serum 25(OH)Vit-D and the risk of fractures in children, and to explore the sources of heterogeneity and investigate their impact on results.
methodsSystematic review and meta-analysis were conducted for observational studies comparing serum 25(OH)Vit-D levels between fracture and non-fracture pediatric cases. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS).
resultsAnalysis on 17 case-control and 6 cross-sectional studies (2929 fracture cases and 5000 controls) suggested that 25(OH)Vit-D was lower in fracture cases than in controls (pooled mean difference (MD) = - 3.51 nmol/L; 95% confidence interval (CI): - 5.60 to - 1.42) with a heterogeneity (I
conclusionThis study indicated that serum 25(OH)Vit-D levels were lower in pediatric patients with fractures. 25(OH)Vit-D ≤ 50 nmol/L was associated with increased fracture risk in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.