ArticleBrain : a journal of neurology2021
The computational neurology of movement under active inference.
Article in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Inferential planning in the frontal cortex.Cell reports · 2026Article
- Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.Brain : a journal of neurology · 2026Review
- In silico models in oncology, neurology, and epidemiology: systems-level and multiscale perspectives.NPJ systems biology and applications · 2026Review
- From neuroinflammation to neural inference: computational psychiatry meets precision medicine.Schizophrenia (Heidelberg, Germany) · 2026Review
- Active inference and speech motor control.Psychonomic bulletin & review · 2026Review
- Towards an active inference account of deep meditative deconstruction.Neuroscience of consciousness · 2026Article
- SPM-30 years and beyond.Cerebral cortex (New York, N.Y. : 1991) · 2025Review
- Priors and proprioceptive predictions.Current opinion in behavioral sciences · 2025Article
- Embodied decisions as active inference.PLoS computational biology · 2025Article
- Article
- Counteracting uncertainty: exploring the impact of anxiety on updating predictions about environmental states.Biological cybernetics · 2025Article
- That's (relevant for) me: task-set-dependent brain responses to delayed visual movement feedback.Social cognitive and affective neuroscience · 2025Article
- An active inference account of stuttering behavior.Frontiers in human neuroscience · 2025Article
- Generative models for sequential dynamics in active inference.Cognitive neurodynamics · 2024Review
- The Many Roles of Precision in Action.Entropy (Basel, Switzerland) · 2024Review
- Collective behavior from surprise minimization.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Association of abnormal explicit sense of agency with cerebellar impairment in myoclonus-dystonia.Brain communications · 2024Article
- Deep kinematic inference affords efficient and scalable control of bodily movements.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Testing predictive coding theories of autism spectrum disorder using models of active inference.PLoS computational biology · 2023Article
- Knee flexion of saxophone players anticipates tonal context of music.NPJ science of learning · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
We propose a computational neurology of movement based on the convergence of theoretical neurobiology and clinical neurology. A significant development in the former is the idea that we can frame brain function as a process of (active) inference, in which the nervous system makes predictions about its sensory data. These predictions depend upon an implicit predictive (generative) model used by the brain. This means neural dynamics can be framed as generating actions to ensure sensations are consistent with these predictions-and adjusting predictions when they are not. We illustrate the significance of this formulation for clinical neurology by simulating a clinical examination of the motor system using an upper limb coordination task. Specifically, we show how tendon reflexes emerge naturally under the right kind of generative model. Through simulated perturbations, pertaining to prior probabilities of this model's variables, we illustrate the emergence of hyperreflexia and pendular reflexes, reminiscent of neurological lesions in the corticospinal tract and cerebellum. We then turn to the computational lesions causing hypokinesia and deficits of coordination. This in silico lesion-deficit analysis provides an opportunity to revisit classic neurological dichotomies (e.g. pyramidal versus extrapyramidal systems) from the perspective of modern approaches to theoretical neurobiology-and our understanding of the neurocomputational architecture of movement control based on first principles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.