ArticleCerebral cortex (New York, N.Y. : 1991)2021
Conduction Velocity Along the Local Axons of Parvalbumin Interneurons Correlates With the Degree of Axonal Myelination.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms.Journal of cell communication and signaling · 2026Review
- CA1 parvalbumin interneurons display alterations of myelin patterning driven by microgliosis in temporal lobe epilepsy.Scientific reports · 2026Article
- Article
- Axon collateralization and focal myelin dystrophy alter action potential propagation in multicompartment pyramidal neuron models.PLoS computational biology · 2025Article
- Transient juvenile demyelination impairs maturation and function of parvalbumin-positive interneurons in the prefrontal cortex.PLoS biology · 2025Article
- PV - Oligodendrocyte Interactions in the Infralimbic Cortex Promote Extracellular Plasticity after Safety Learning.bioRxiv : the preprint server for biology · 2025Article
- Plasticity of Myelination.Advances in neurobiology · 2025Review
- Array tomography: trails to discovery.Methods in microscopy · 2024Article
- Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer's disease.Molecular psychiatry · 2023Review
- A class-specific effect of dysmyelination on the excitability of hippocampal interneurons.eLife · 2023Article
- Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes.Communications biology · 2023Article
- Bringing synapses into focus: Recent advances in synaptic imaging and mass-spectrometry for studying synaptopathy.Frontiers in synaptic neuroscience · 2023Review
- Anti-Correlated Myelin-Sensitive MRI Levels in Humans Consistent with a Subcortical to Sensorimotor Regulatory Process-Multi-Cohort Multi-Modal Evidence.Brain sciences · 2022Article
- Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes.Nature communications · 2022Article
- Review
- Array tomography: 15 years of synaptic analysis.Neuronal signaling · 2022Article
- Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition.eLife · 2022Article
- Clustered Intrinsic Connections: Not a Single System.Frontiers in systems neuroscience · 2022Article
- Extensive Structural Remodeling of the Axonal Arbors of Parvalbumin Basket Cells during Development in Mouse Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net.Brain structure & function · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Parvalbumin-containing (PV+) basket cells in mammalian neocortex are fast-spiking interneurons that regulate the activity of local neuronal circuits in multiple ways. Even though PV+ basket cells are locally projecting interneurons, their axons are myelinated. Can this myelination contribute in any significant way to the speed of action potential propagation along such short axons? We used dual whole cell recordings of synaptically connected PV+ interneurons and their postsynaptic target in acutely prepared neocortical slices from adult mice to measure the amplitude and latency of single presynaptic action potential-evoked inhibitory postsynaptic currents. These same neurons were then imaged with immunofluorescent array tomography, the synapses between them identified and a precise map of the connections was generated, with the exact axonal length and extent of myelin coverage. Our results support that myelination of PV+ basket cells significantly increases conduction velocity, and does so to a degree that can be physiologically relevant.
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Registered trials
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