Evidence map›Paper›PMID 33704190›Full record

ArticleCurrent oncology (Toronto, Ont.)2020

Genomic and Clinical Correlates of Adrenocortical Carcinoma in an Adult Patient with Li-Fraumeni Syndrome: A Case Report.

Suraya Bondy, Camilla Tajzler, Sebastien J Hotte, Anil Kapoor, Kevin Zbuk, Aly-Khan A Lalani

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Suraya BondyFaculty of Health Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.
Camilla TajzlerDivision of Urology, Department of Surgery, McMaster University, Hamilton, ON L8S 4L8, Canada.
Sebastien J HotteDivision of Medical Oncology, Department of Oncology, McMaster University, Hamilton, ON L8V 5C2, Canada.
Anil KapoorDivision of Urology, Department of Surgery, McMaster University, Hamilton, ON L8S 4L8, Canada.ORCID 0000-0001-9180-8029
Kevin ZbukDivision of Medical Oncology, Department of Oncology, McMaster University, Hamilton, ON L8V 5C2, Canada.
Aly-Khan A LalaniDivision of Medical Oncology, Department of Oncology, McMaster University, Hamilton, ON L8V 5C2, Canada.ORCID 0000-0002-9907-9112
McMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Li-Fraumeni Syndrome (LFS) is defined by germline mutations of the p53 tumour suppressor gene. Adrenocortical carcinoma (ACC) is a rare aggressive malignancy that is commonly associated with LFS. Most LFS-linked ACC cases occur in children, and limited research has been dedicated to the clinical outcomes and genomics of adult cases with LFS-linked ACC. We report on a 34-year-old female who was diagnosed with three separate malignancies: stage III invasive ductal carcinoma of the right breast, metastatic ACC from the right adrenal gland, and grade 2 pleomorphic sarcoma of the left hand. Her invasive breast ductal carcinoma was treated with neoadjuvant chemotherapy, and she received a bilateral mastectomy after her LFS was confirmed with genetic blood testing. Adrenal ACC was initially treated with a right nephrectomy and adrenalectomy, followed by adjuvant mitotane and two lines of chemotherapy after disease recurrence. Her hand sarcoma was treated by second ray amputation. Further, we conducted deep next-generation sequencing of each of her unique tumour tissue samples using FoundationONE CDx. A whole-genome shot capture followed by in vitro sequencing performed by the Illumina

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical CarcinomaBreast NeoplasmsLi-Fraumeni SyndromeAdultFemaleGenomicsHumansMastectomyNeoplasm Recurrence, Localadrenocortical carcinomaLi-Fraumeni Syndromenext-generation sequencing

Identifiers

PMID33704190
PMCPMC7900890
OpenAlexW3116910069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.