ArticleJournal of behavioral addictions2021
Gender-related differences in frontal-parietal modular segregation and altered effective connectivity in internet gaming disorder.
Article in Journal of behavioral addictions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Prevalence of gaming disorder in East Asia: A comprehensive meta-analysis.Journal of behavioral addictions · 2022Pooled it
- Examining the Association Between Internet Addiction and Nonsuicidal Self-Injury Among Chinese Middle School Students: Prospective Cohort Study.Journal of medical Internet research · 2026Article
- Functional magnetic resonance imaging in adolescent Internet gaming disorder: A systematic review.Addictive behaviors reports · 2025Review
- The middle frontal gyrus as a neural mediator between family relationships and internet addiction among adolescents with internet gaming disorder: a cross-sectional study.BMC psychology · 2025Article
- The mediation role of low social-connectedness in association of internet gaming disorder and anger among adolescents: a multi-centre, large-sample and cross-sectional study.BMC public health · 2025Article
- Altered integrated and segregated states in cocaine use disorder.Frontiers in neuroscience · 2025Article
- Biomarkers of Internet Gaming Disorder-A Narrative Review.Journal of clinical medicine · 2024Review
- Different cortical connectivities in human females and males relate to differences in strength and body composition, reward and emotional systems, and memory.Brain structure & function · 2024Article
- Sex differences of neural connectivity in internet gaming disorder and its association with sleep quality: an exploratory fMRI study.Frontiers in psychiatry · 2024Article
- Neuroimaging correlates of internet gaming disorder: Can we achieve the promise of translating understandings of brain functioning into clinical advances?The Canadian journal of addiction · 2023Article
- Associations between levels of Internet Gaming Disorder symptoms and striatal morphology-replication and associations with social anxiety.Psychoradiology · 2022Article
- Neural activations to loss anticipation mediates the association between difficulties in emotion regulation and screen media activities among early adolescent youth: A moderating role for depression.Developmental cognitive neuroscience · 2022Article
- Decreased modular segregation of the frontal-parietal network in major depressive disorder.Frontiers in psychiatry · 2022Article
- Dorsal and ventral striatal functional connectivity shifts play a potential role in internet gaming disorder.Communications biology · 2021Article
- Relationship Between Gaming Disorder, Self-Compensation Motivation, Game Flow, Time Spent Gaming, and Fear of Missing Out Among a Sample of Chinese University Students: A Network Analysis.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough previous studies have revealed gender-related differences in executive function in internet gaming disorder (IGD), neural mechanisms underlying these processes remain unclear, especially in terms of brain networks.
methodsResting-state fMRI data were collected from 78 subjects with IGD (39 males, 20.8 ± 2.16 years old) and 72 with recreational game use (RGU) (39 males, 21.5 ± 2.56 years old). By utilizing graph theory, we calculated participation coefficients among brain network modules for all participants and analyzed the diagnostic-group-by-gender interactions. We further explored possible causal relationships between networks through spectral dynamic causal modeling (spDCM) to assess differences in between-network connections.
resultsCompared to males with RGU, males with IGD demonstrated reduced modular segregation of the frontal-parietal network (FPN). Male IGD subjects also showed increased connections between the FPN and cingulo-opercular network (CON); however, these differences were not found in female subjects. Further spDCM analysis indicated that the causal influence from CON to FPN in male IGD subjects was enhanced relative to that of RGU males, while this influence was relatively reduced in females with IGD.
conclusionsThese results suggest poor modular segmentation of the FPN and abnormal FPN/CON connections in males with IGD, suggesting a mechanism for male vulnerability to IGD. An increased "bottom-up" effect from the CON to FPN in male IGD subjects could reflect dysfunction between the brain networks. Different mechanisms may underlie in IGD, suggesting that different interventions may be optimal in males and females with IGD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.