Evidence map›Paper›PMID 33704066›Full record

ArticleeLife2021

Single-molecule view of coordination in a multi-functional DNA polymerase.

Raymond F Pauszek, Rajan Lamichhane, Arishma Rajkarnikar Singh, David P Millar

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. DNA polymerase I: structure, activity, and function in bacterial DNA replication and repair.Critical reviews in biochemistry and molecular biology · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Structural and Molecular Kinetic Features of Activities of DNA Polymerases.International journal of molecular sciences · 2022
    Review
  6. Slow conformational dynamics of the human AStructure (London, England : 1993) · 2022
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Raymond F PauszekDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.ORCID 0000-0002-3445-8429
Rajan LamichhaneDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.ORCID 0000-0003-0089-6452
Arishma Rajkarnikar SinghDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.
David P MillarDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.ORCID 0000-0001-9207-6958
Scripps Research Institute · US

Funding

MOLECULAR BASIS OF VIRAL PATHOGENESIST32AI007354 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 1989 to 2020
$5.2M
Understanding Functional Coordination in a Multifunctional DNA PolymeraseR01GM044060 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI MILLAR, DAVID P · 1992 to 2017
$5.0M
Single-molecule conformational dynamics of DNA polymeraseF32GM115017 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI PAUSZEK, RAYMOND FRANCIS · 2016 to 2017
$115k
NIAID NIH HHS T32 AI007354NIGMS NIH HHS F32 GM115017NIGMS NIH HHS R01 GM044060
6 · The paper itself

Abstract

Replication and repair of genomic DNA requires the actions of multiple enzymatic functions that must be coordinated in order to ensure efficient and accurate product formation. Here, we have used single-molecule FRET microscopy to investigate the physical basis of functional coordination in DNA polymerase I (Pol I) from

Indexed as

DNA Polymerase IEscherichia coliEscherichia coli ProteinsSingle Molecule ImagingDNA Polymerase IEscherichia coli ProteinsDNA polymeraseE. colifunctional coordinationmolecular biophysicssingle-molecule FRETstructural biology

Identifiers

PMID33704066
PMCPMC7952088
OpenAlexW3134500795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.