ArticleeLife2021
Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 74 citations in OpenAlex.
- Mechanics of compression-driven morphogenesis.Development (Cambridge, England) · 2026Review
- Mechanical constraints regulate embryonic stem cell mitosis in the developing brain.The EMBO journal · 2026Article
- A minimal mechanically consistent model of smoothly dividing disk-shaped cells.NPJ systems biology and applications · 2026Article
- Stress-dependent growth in breast cancer arises from a mechano-osmotic coupling and cell-sizing checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Metabolic starvation-induced cell swelling drives solid stress in tumors.bioRxiv : the preprint server for biology · 2026Article
- Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids.Nature cell biology · 2026Article
- Brillouin Microscopy of Breast tumor Spheroids On-a-Chip: Mechanical and Transcriptional Responses to Microfluidic-Induced Rapid Deformations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Novel Diffuse Midline Glioma-on-Chip Recapitulating Tumor Biophysical Microenvironment to Assess the Heterogeneity of Response to Therapies.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Surface mechanics and compressive stress impact mammalian follicle development.Nature communications · 2025Article
- Article
- Cell condensation initiates organogenesis: the role of actin dynamics in supracellular self-organizing process.Cell & bioscience · 2025Review
- Surface tension-driven boundary growth in tumour spheroids.Interface focus · 2025Article
- Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology.Nature biomedical engineering · 2025Article
- Compressive stresses in cancer: characterization and implications for tumour progression and treatment.Nature reviews. Cancer · 2024Review
- Epithelial cell-cell interactions in an overcrowded environment: jamming or live cell extrusion.Journal of biological engineering · 2024Review
- A dynamic network model predicts the phenotypes of multicellular clusters from cellular properties.Current biology : CB · 2024Article
- Mechanical models and measurement methods of solid stress in tumors.Applied microbiology and biotechnology · 2024Review
- A two-phase thin-film model for cell-induced gel contraction incorporating osmotic effects.Journal of mathematical biology · 2024Article
- Role of viscoelasticity in the appearance of low-Reynolds turbulence: considerations for modelling.Journal of biological engineering · 2024Review
- Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development.Nature cell biology · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imposed deformations play an important role in morphogenesis and tissue homeostasis, both in normal and pathological conditions. To perceive mechanical perturbations of different types and magnitudes, tissues need appropriate detectors, with a compliance that matches the perturbation amplitude. By comparing results of selective osmotic compressions of CT26 mouse cells within multicellular aggregates and global aggregate compressions, we show that global compressions have a strong impact on the aggregates growth and internal cell motility, while selective compressions of same magnitude have almost no effect. Both compressions alter the volume of individual cells in the same way over a shor-timescale, but, by draining the water out of the extracellular matrix, the global one imposes a residual compressive mechanical stress on the cells over a long-timescale, while the selective one does not. We conclude that the extracellular matrix is as a sensor that mechanically regulates cell proliferation and migration in a 3D environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.