ArticleNeurorehabilitation and neural repair2021
Ipsilateral Motor Pathways and Transcallosal Inhibition During Lower Limb Movement After Stroke.
Article in Neurorehabilitation and neural repair, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Association of Interhemispheric Structural Integrity With Transcallosal Interhemispheric Inhibition in People With Chronic Stroke.Journal of neuroscience research · 2026Article
- Robotic Ankle Assessment Post-Stroke: Reliability, Comparison to Therapists, and Benchmark Dataset Development.Sensors (Basel, Switzerland) · 2025Article
- Article
- Functional connectivity of proximal and distal lower limb muscles and impact on gait variability in stroke.Gait & posture · 2023Article
- Targeting CNS Neural Mechanisms of Gait in Stroke Neurorehabilitation.Brain sciences · 2022Article
- Motor overflow in the lower limb after stroke: Insights into mechanisms.The European journal of neuroscience · 2022Article
- Role of the Contra-Lesional Corticoreticular Tract in Motor Recovery of the Paretic Leg in Stroke: A Mini-Narrative Review.Frontiers in human neuroscience · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundStroke rehabilitation may be improved with a better understanding of the contribution of ipsilateral motor pathways to the paretic limb and alterations in transcallosal inhibition. Few studies have evaluated these factors during dynamic, bilateral lower limb movements, and it is unclear whether they relate to functional outcomes.
objectiveDetermine if lower limb ipsilateral excitability and transcallosal inhibition after stroke depend on target limb, task, or number of limbs involved, and whether these factors are related to clinical measures.
methodsIn 29 individuals with stroke, ipsilateral and contralateral responses to transcranial magnetic stimulation were measured in the paretic and nonparetic tibialis anterior during dynamic (unilateral or bilateral ankle dorsiflexion/plantarflexion) and isometric (unilateral dorsiflexion) conditions. Relative ipsilateral excitability and transcallosal inhibition were assessed. Fugl-Meyer, ankle movement accuracy, and walking characteristics were assessed.
resultsRelative ipsilateral excitability was greater during dynamic than isometric conditions in the paretic limb (
conclusionsIpsilateral pathways have increased excitability to the paretic limb, particularly during dynamic tasks. Transcallosal inhibition is greater in the ipsilesional than contralesional hemisphere and during dynamic than isometric tasks. Ipsilateral pathways and transcallosal inhibition may influence walking asymmetry and ankle movement accuracy.
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Registered trials
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