SynthesisJournal of applied physiology (Bethesda, Md. : 1985)2021
Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review.
Synthesis in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effect of exercise-based interventions on stroke rehabilitation: an umbrella review of systematic reviews and meta-analyses.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Resistance exercise training improves disuse-induced skeletal muscle atrophy in humans: a meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2025Pooled it
- Plantar flexor strength and size decrease following single-leg disuse in uninjured adults: A meta-analysis.Clinical physiology and functional imaging · 2025Pooled it
- Interpersonal relationships as coping mechanisms during bed rest: a thematic synthesis literature review.Frontiers in psychology · 2024Pooled it
- Effects of Bed Rest on Physical Performance in Athletes: A Systematic and Narrative Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Effects of short-term hand immobilization on motor functions across domains in adults.Physiological reports · 2026Trial
- Artificial gravity during prolonged bed rest preserves resting metabolic rate but not muscle function: Evidence from the BRACE study.The Journal of physiology · 2026Trial
- Limited musculoskeletal benefits of artificial gravity combined with cycling during bed rest: Results from the BRACE study.Experimental physiology · 2026Trial
- Trial
- Network Reconfiguration Underlies Compensatory Muscle Control Across Force Gradients: Parallel Functional Network Evidence from EEG and sEMG.Annals of biomedical engineering · 2026Article
- Physical Activity and Nutritional Supportive Care Needs Following a Sarcoma Diagnosis: Barriers and Opportunities for Rare Cancer Survivorship Care.Psycho-oncology · 2026Article
- Muscle fibre denervation in ageing.Clinical science (London, England : 1979) · 2026Review
- Body Mass Index-Adjusted Rectus Femoris Muscle Thickness as a Simple Indicator for Exercise Tolerance in Patients With Heart Failure.Circulation reports · 2026Article
- Comparison of musculoskeletal responses and its variability after long-term spaceflight and prolonged bed rest conditions.NPJ microgravity · 2026Article
- Impact of Seven-Day Versus Five-Day Inpatient Physiotherapy: A Review of Clinical and Economic Outcomes.Cureus · 2026Review
- Review
- Associations between orthostatic hypotension and related factors in hospitalised older adults: a cross-sectional study in Turkey.BMC geriatrics · 2026Article
- Assessment of Lower Limb Muscle Volume Using 3D Ultrasonography: Validity and Reliability Compared to MRI.Journal of imaging informatics in medicine · 2026Article
- Impact of 14 days of head-down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults.Experimental physiology · 2026Article
- The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2026Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle atrophy and decline in muscle strength appear very rapidly with prolonged disuse or mechanical unloading after acute hospitalization or experimental bed rest. The current study analyzed data from short-, medium-, and long-term bed rest (5-120 days) in a pooled sample of 318 healthy adults and modeled the mathematical relationship between muscle strength decline and atrophy. The results show a logarithmic disuse-induced loss of strength and muscle atrophy of the weight-bearing knee extensor muscles. The greatest rate of muscle strength decline and atrophy occurred in the earliest stages of bed rest, plateauing later, and likely contributed to the rapid neuromuscular loss of function in the early period. In addition, during the first 2 wk of bed rest, muscle strength decline is much faster than muscle atrophy: on
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.