ArticlePlant physiology2021
UGT84F9 is the major flavonoid UDP-glucuronosyltransferase in Medicago truncatula.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Flavonoid-Rich Metabolite Profiling and Anti-Inflammatory Activity ofMolecules (Basel, Switzerland) · 2026Article
- Identification and Characterization of a Putative Kaempferol Glucosyltransferase UGT78G3 inPlants (Basel, Switzerland) · 2026Article
- Optimization of an Extraction Protocol for Untargeted Metabolomics ofPlants (Basel, Switzerland) · 2026Article
- Disentangling direct and pleiotropic SNP effects in alfalfa (Medicago sativa L.) using causal graph learning.Scientific reports · 2026Article
- Review
- Comprehensive mutant chemotyping reveals embedding of a lineage-specific biosynthetic gene cluster in wider plant metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- A century of studying plant secondary metabolism-From "what?" to "where, how, and why?"Plant physiology · 2024Review
- Inhibition of Uridine 5'-diphospho-glucuronosyltransferases A10 and B7 by vitamins: insights from in silico and in vitro studies.In silico pharmacology · 2024Article
- Evaluation of pathways to thePlant direct · 2022Article
- Genome-wide identification, characterization, and expression analysis of UDP-glycosyltransferase genes associated with secondary metabolism in alfalfa (Frontiers in plant science · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mammalian phase II metabolism of dietary plant flavonoid compounds generally involves substitution with glucuronic acid. In contrast, flavonoids mainly exist as glucose conjugates in plants, and few plant UDP-glucuronosyltransferase enzymes have been identified to date. In the model legume Medicago truncatula, the major flavonoid compounds in the aerial parts of the plant are glucuronides of the flavones apigenin and luteolin. Here we show that the M. truncatula glycosyltransferase UGT84F9 is a bi-functional glucosyl/glucuronosyl transferase in vitro, with activity against a wide range of flavonoid acceptor molecules including flavones. However, analysis of metabolite profiles in leaves and roots of M. truncatula ugt84f9 loss of function mutants revealed that the enzyme is essential for formation of flavonoid glucuronides, but not most flavonoid glucosides, in planta. We discuss the use of plant UGATs for the semi-synthesis of flavonoid phase II metabolites for clinical studies.
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