ArticleThe journal of obstetrics and gynaecology research2021
Expression and significance of microRNA-126 and VCAM-1 in placental tissues of women with early-onset preeclampsia.
Article in The journal of obstetrics and gynaecology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Changes in microRNA expression associated with preeclampsia: a systematic review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Pooled it
- First trimester maternal serum MicroRNA expression and pre-eclampsia: a retrospective nested case-control study.BMC pregnancy and childbirth · 2025Article
- Development and validation of nomograms to predict clinical outcomes of preeclampsia.Frontiers in endocrinology · 2024Article
- The function of miRNAs in the immune system's inflammatory reaction to heart failure.Frontiers in cardiovascular medicine · 2024Review
- The Role of ncRNAs in the Immune Dysregulation of Preeclampsia.International journal of molecular sciences · 2023Review
- Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review).Experimental and therapeutic medicine · 2023Review
- A microphysiological model of human trophoblast invasion during implantation.Nature communications · 2022Article
- Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia.Frontiers in cell and developmental biology · 2022Review
- Endothelial Dysfunction in Pregnancy Complications.Biomedicines · 2021Review
- Preeclamptic Women Have Disrupted Placental microRNA Expression at the Time of Preeclampsia Diagnosis: Meta-Analysis.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the expression of microRNA-126 (miR-126) and vascular endothelial cell adhesion molecule-1 (VCAM-1) in the placental tissues of women with early-onset preeclampsia (EOPE) and their effects on trophoblast invasion. MATERIALS AND
methodsThe placental tissues of 30 pregnant women with EOPE who delivered in the Third Affiliated Hospital of Zhengzhou University from November 2019 to May 2020 were selected as the preeclampsia (PE) group, and the placental tissues of 30 healthy pregnant women with normal prenatal examination were selected as the normal group. Immunohistochemistry was used to localize VCAM-1 in placental tissues，the expression of miR-126 and VCAM-1 in placenta tissues of two groups and HTR-8/SVneo cells transfected with miR-126 were detected by real-time polymerase chain reaction (RT-PCR) and Western blot, and the correlation between them was analyzed. The invasion ability of cells transfected with miR-126 was observed by Transwell invasion test.
resultsCompared with the normal group, the expression of miR-126 was higher and VCAM-1 was lower in the placental tissues of the PE group, and the difference were statistically significant (p < 0.01). Moreover, VCAM-1 was negatively correlated with the expression of miR-126 (r = -0.391, p < 0.05). In vitro experiment, the expression level of VCAM-1 in miR-126 mimics transfection group was decreased, and the expression level of VCAM-1 in miR-126 inhibitor transfection group was increased; the invasion ability of HTR-8/SVneo cells transfected with miR-126 mimics was decreased, and the invasion ability of HTR-8/SVneo cells transfected with miR-126 inhibitor was enhanced.
conclusionThere was a negative correlation between the expression of miR-126 and VCAM-1 in EOPE.MiR-126 and VCAM-1 may participate in the occurrence and development of EOPE by affecting the invasion ability of trophoblast cells.
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