Evidence map›Paper›PMID 33694178›Full record

ArticleStatistics in medicine2021

Reduced rank multinomial logistic regression in Markov chains with application to cognitive data.

Pei Wang, Erin L Abner, David W Fardo, Frederick A Schmitt, Gregory A Jicha, Linda J Van Eldik, Richard J Kryscio

Abstract read
In one paragraph

Article in Statistics in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pei WangDepartment of Statistics, University of Kentucky, Lexington, Kentucky, USA.
Erin L AbnerDepartment of Epidemiology, University of Kentucky, Lexington, Kentucky, USA.
David W FardoAlzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Frederick A SchmittAlzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Gregory A JichaAlzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Linda J Van EldikAlzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Richard J KryscioDepartment of Statistics, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-2775-1184

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, VAN ELDIK, LINDA J · 2006 to 2020
$23.3M
Role of impaired cognitive states & risk factors in conversion to mixed dementiasR01AG038651 · NIA · UNIVERSITY OF KENTUCKY · PI ABNER, ERIN, KRYSCIO, RICHARD J. · 2011 to 2023
$6.1M
Genomic Architecture of a Key Alzheimer's Disease Mimic: CARTSR56AG057191 · NIA · UNIVERSITY OF KENTUCKY · PI FARDO, DAVID WILLIAM · 2019 to 2020
$1.1M
NCATS NIH HHS UL1 TR001998NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG038651NIA NIH HHS R56 AG057191
6 · The paper itself

Abstract

Finite Markov chains are useful tools for studying transitions among health states; these chains can be complex consisting of a mix of transient and absorbing states. The transition probabilities, which are often affected by covariates, can be difficult to estimate due to the presence of many covariates and/or a subset of transitions that are rarely observed. The purpose of this article is to show how to estimate the effect of a subset of covariates of interest after adjusting for the presence of multiple other covariates by applying multidimensional dimension reduction to the latter. The case in which transitions within each row of the one-step transition probability matrix are estimated by multinomial logistic regression is discussed in detail. Dimension reduction for the adjustment covariates involves estimating the effect of the covariates by a product of matrices iteratively; at each iteration one matrix in the product is fixed while the second is estimated using either standard software or nonlinear estimation, depending on which of the matrices in the product is fixed. The algorithm is illustrated by an application where the effect of at least one Apolipoprotein-E (APOE) gene

Indexed as

Cognitive DysfunctionCognitionCohort StudiesHumansLogistic ModelsMarkov Chainscognitive assessmentsdementiaMarkov chainsmultinomial logistic regressionreduced rank

Identifiers

PMID33694178
PMCPMC8607544

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.