Evidence map›Paper›PMID 33694073›Full record

ArticleJournal of mathematical biology2021

Time dependent asymptotic analysis of the gene regulatory network of the AcrAB-TolC efflux pump system in gram-negative bacteria.

George H Youlden, Vito Ricci, Xuan Wang-Kan, Laura J V Piddock, Sara Jabbari, John R King

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of mathematical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

George H YouldenSchool of Mathematics, University of Birmingham, Birmingham, B15 2TT, UK. ghy245@student.bham.ac.uk.ORCID 0000-0002-1652-1949
Vito RicciInstitute of Microbiology and Infection, University of Birmingham, Birmingham, B15 2TT, UK.
Xuan Wang-KanInstitute of Microbiology and Infection, University of Birmingham, Birmingham, B15 2TT, UK.
Laura J V PiddockInstitute of Microbiology and Infection, University of Birmingham, Birmingham, B15 2TT, UK.
Sara JabbariSchool of Mathematics, University of Birmingham, Birmingham, B15 2TT, UK.
John R KingSchool of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
University of Birmingham · GBUniversity of Nottingham · GBLudwig Cancer Research · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M021386/1Engineering and Physical Sciences Research Council EP/N509590/1Medical Research Council MR/P022596/1
6 · The paper itself

Abstract

Efflux pumps are a mechanism of intrinsic and evolved resistance in bacteria. If an efflux pump can expel an antibiotic so that its concentration within the cell is below a killing threshold the bacteria are resistant to the antibiotic. Efflux pumps may be specific or they may pump various different substances. This is why many efflux pumps confer multi drug resistance (MDR). In particular over expression of the AcrAB-TolC efflux pump system confers MDR in both Salmonella and Escherichia coli. We consider the complex gene regulation network that controls expression of genes central to controlling the efflux associated genes acrAB and acrEF in Salmonella. We present the first mathematical model of this gene regulatory network in the form of a system of ordinary differential equations. Using a time dependent asymptotic analysis, we examine in detail the behaviour of the efflux system on various different timescales. Asymptotic approximations of the steady states provide an analytical comparison of targets for efflux inhibition.

Indexed as

Escherichia coli ProteinsGene Regulatory NetworksModels, BiologicalAnti-Bacterial AgentsBacterial ProteinsEscherichia coliGram-Negative BacteriaMembrane Transport ProteinsSalmonellaTimeAnti-Bacterial AgentsBacterial ProteinsEscherichia coli ProteinsMembrane Transport ProteinsAcrAB-TolCAsymptotic analysisEscherichia coliMathematical modellingSalmonella

Identifiers

PMID33694073
PMCPMC7946726
OpenAlexW3135086474

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.