Evidence map›Paper›PMID 33694015›Full record

ArticleJournal of mathematical biology2021

Dynamics of ERK regulation in the processive limit.

Carsten Conradi, Nida Obatake, Anne Shiu, Xiaoxian Tang

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of mathematical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Algebra, Geometry and Topology of ERK Kinetics.Bulletin of mathematical biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Carsten ConradiHTW Berlin, Berlin, Germany.
Nida ObatakeDepartment of Mathematics, Texas A&M University, College Station, USA.
Anne ShiuDepartment of Mathematics, Texas A&M University, College Station, USA.
Xiaoxian TangDepartment of Mathematics, Texas A&M University, College Station, USA. xiaoxiantang@icloud.com.ORCID 0000-0002-9873-7056
Texas A&M University · USBeihang University · CNHTW Berlin - University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We consider a model of extracellular signal-regulated kinase regulation by dual-site phosphorylation and dephosphorylation, which exhibits bistability and oscillations, but loses these properties in the limit in which the mechanisms underlying phosphorylation and dephosphorylation become processive. Our results suggest that anywhere along the way to becoming processive, the model remains bistable and oscillatory. More precisely, in simplified versions of the model, precursors to bistability and oscillations (specifically, multistationarity and Hopf bifurcations, respectively) exist at all "processivity levels". Finally, we investigate whether bistability and oscillations can exist together.

Indexed as

Extracellular Signal-Regulated MAP KinasesModels, BiologicalPhosphorylationExtracellular Signal-Regulated MAP KinasesBistabilityChemical reaction networkExtracellular signal-regulated kinaseHopf bifurcationOscillation

Identifiers

PMID33694015
OpenAlexW2982506246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.