Evidence map›Paper›PMID 33693966›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2021

Structural and functional radiomics for lung cancer.

Guangyao Wu, Arthur Jochems, Turkey Refaee, Abdalla Ibrahim, Chenggong Yan, Sebastian Sanduleanu, Henry C Woodruff, Philippe Lambin

Abstract readReview
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Radiomics of pituitary adenoma using computer vision: a review.Medical & biological engineering & computing · 2024
    Pooled it
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  19. Advancements and future trends in machine learning for lung cancer: a comprehensive bibliometric analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guangyao WuThe D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University Medical Centre+, 6229, Maastricht, The Netherlands. g.wu@maastrichtuniversity.nl.
Arthur Jochems *The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University Medical Centre+, 6229, Maastricht, The Netherlands.
Turkey Refaee *The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University Medical Centre+, 6229, Maastricht, The Netherlands.
Abdalla IbrahimThe D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University Medical Centre+, 6229, Maastricht, The Netherlands.
Chenggong YanThe D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University Medical Centre+, 6229, Maastricht, The Netherlands.
Sebastian SanduleanuThe D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University Medical Centre+, 6229, Maastricht, The Netherlands.
Henry C Woodruff *The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University Medical Centre+, 6229, Maastricht, The Netherlands.
Philippe Lambin *The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University Medical Centre+, 6229, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLung cancer ranks second in new cancer cases and first in cancer-related deaths worldwide. Precision medicine is working on altering treatment approaches and improving outcomes in this patient population. Radiological images are a powerful non-invasive tool in the screening and diagnosis of early-stage lung cancer, treatment strategy support, prognosis assessment, and follow-up for advanced-stage lung cancer. Recently, radiological features have evolved from solely semantic to include (handcrafted and deep) radiomic features. Radiomics entails the extraction and analysis of quantitative features from medical images using mathematical and machine learning methods to explore possible ties with biology and clinical outcomes.

methodsHere, we outline the latest applications of both structural and functional radiomics in detection, diagnosis, and prediction of pathology, gene mutation, treatment strategy, follow-up, treatment response evaluation, and prognosis in the field of lung cancer.

conclusionThe major drawbacks of radiomics are the lack of large datasets with high-quality data, standardization of methodology, the black-box nature of deep learning, and reproducibility. The prerequisite for the clinical implementation of radiomics is that these limitations are addressed. Future directions include a safer and more efficient model-training mode, merge multi-modality images, and combined multi-discipline or multi-omics to form "Medomics."

Indexed as

Lung NeoplasmsHumansLungMachine LearningPrognosisReproducibility of ResultsArtificial intelligenceLung cancerMedical imagingRadiomics

Identifiers

PMID33693966
PMCPMC8484174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.