Evidence map›Paper›PMID 33693965›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Stereotactic radiotherapy to oligoprogressive lesions detected with

Cem Onal, Gokhan Ozyigit, Ezgi Oymak, Ozan Cem Guler, Burak Tilki, Pervin Hurmuz, Fadil Akyol

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  14. Reply to "Letter to the editor regarding 'Stereotactic radiosurgery for bone metastases in oligometastatic prostate cancer patients: DESTROY-2 clinical trial subanalysis'".Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
  15. Letter to the editor regarding 'Stereotactic radiosurgery for bone metastases in oligometastatic prostate cancer patients: DESTROY‑2 clinical trial subanalysis'.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
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  16. The Promise of Metastasis-Directed Therapy for Oligometastatic Prostate Cancer: Going Beneath the Surface with Molecular Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Cem OnalDepartment of Radiation Oncology, Adana Dr. Turgut Noyan Research and Treatment Center, Baskent University Faculty of Medicine, 01120, Adana, Turkey. hcemonal@hotmail.com.ORCID 0000-0002-2742-9021
Gokhan OzyigitDepartment of Radiation Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Ezgi OymakDivision of Radiation Oncology, Iskenderun Gelisim Hospital, Hatay, Turkey.
Ozan Cem GulerDepartment of Radiation Oncology, Adana Dr. Turgut Noyan Research and Treatment Center, Baskent University Faculty of Medicine, 01120, Adana, Turkey.
Burak TilkiDepartment of Radiation Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Pervin HurmuzDepartment of Radiation Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Fadil AkyolDepartment of Radiation Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Hacettepe University · TRBaşkent University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe assessed the outcomes of stereotactic body radiotherapy (SBRT) to treat oligoprogressive castration-resistant prostate cancer (CRPC) patients with ≤5 lesions using gallium prostate-specific membrane antigen-positron emission tomography (

methodsThe clinical data of 67 CRPC patients with 133 lesions treated with

resultsWith a median follow-up of 17.5 months, the 2-year overall survival (OS) and PFS rates were 86.9% and 34.4%, respectively. The PSA response was observed in 49 patients (73.1%). Progression was observed in 37 patients (55.2%) at a median of 11.0 months following SBRT. A total of 45 patients (67.2%) remained on ADT after SBRT, and 22 patients (32.8%) had a NEST change at a median of 16.4 months after metastasis-directed treatment (MDT). Patients with a NEST change had higher post-SBRT PSA values and fewer PSA nadirs after MDT than their counterparts. In multivariate analysis, higher pre-SBRT PSA values were the only significant predictor for worse OS and NEST-FS, and no significant factor was found for PFS. No serious acute or late toxicities were observed.

conclusionThis study demonstrated the feasibility of MDT using SBRT to treat oligoprogressive lesions by

Indexed as

Prostatic NeoplasmsProstatic Neoplasms, Castration-ResistantRadiosurgeryAndrogen AntagonistsGallium IsotopesGallium RadioisotopesHumansMalePositron Emission Tomography Computed TomographyRetrospective StudiesTomography, X-Ray ComputedAndrogen Antagonistsgallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesCastration-resistantOligometastasisOligoprogressionProstate cancerStereotactic body radiotherapy

Identifiers

PMID33693965
OpenAlexW3133555677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.