ArticlePlant & cell physiology2021
Downregulation of the E2 Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon-Nitrogen Metabolism in Arabidopsis thaliana.
Article in Plant & cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 23 citations in OpenAlex.
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- Multifaceted role of Trichoderma harzianum isolates in mitigating drought stress and promoting adaptive responses in barley cultivars.Scientific reports · 2025Article
- Exploring associations between metabolites and gene transcripts of common bean (Phaseolus vulgaris L.) in response to rust (Uromyces appendiculatus) infection.BMC plant biology · 2025Article
- The origins and spread of the opium poppy (Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Biochemical and Epigenetic Regulation of Glutamate Metabolism in Maize (Plants (Basel, Switzerland) · 2024Article
- Comparative transcriptome and coexpression network analysis revealed the regulatory mechanism of Astragalus cicer L. in response to salt stress.BMC plant biology · 2024Article
- Mitochondria in photosynthetic cells: Coordinating redox control and energy balance.Plant physiology · 2023Article
- Comparative genomic analysis of the tricarboxylic acid cycle members in four Solanaceae vegetable crops and expression pattern analysis in Solanum tuberosum.BMC genomics · 2021Article
- Abolishing ANAC017-Mediated Mitochondria Retrograde Signalling Alleviates Ammonium Toxicity in Arabidopsis thaliana.Physiologia plantarumArticle
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
In Arabidopsis thaliana, two genes encode the E2 subunit of the 2-oxoglutarate dehydrogenase (2-OGDH), a multimeric complex composed of three subunits. To functionally characterize the isoforms of E2 subunit, we isolated Arabidopsis mutant lines for each gene encoding the E2 subunit and performed a detailed molecular and physiological characterization of the plants under controlled growth conditions. The functional lack of expression of E2 subunit isoforms of 2-OGDH increased plant growth, reduced dark respiration and altered carbohydrate metabolism without changes in the photosynthetic rate. Interestingly, plants from e2-ogdh lines also exhibited reduced seed weight without alterations in total seed number. We additionally observed that downregulation of 2-OGDH activity led to minor changes in the levels of tricarboxylic acid cycle intermediates without clear correlation with the reduced expression of specific E2-OGDH isoforms. Furthermore, the e2-ogdh mutant lines exhibited a reduction by up to 25% in the leaf total amino acids without consistent changes in the amino acid profile. Taken together, our results indicate that the two isoforms of E2 subunit play a similar role in carbon-nitrogen metabolism, in plant growth and in seed weight.
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