Evidence map›Paper›PMID 33693638›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021

Updating and Validating the U.S. Veterans Affairs Frailty Index: Transitioning From ICD-9 to ICD-10.

David Cheng, Clark DuMontier, Cenk Yildirim, Brian Charest, Chelsea E Hawley, Min Zhuo, Julie M Paik, Enzo Yaksic, J Michael Gaziano, Nhan Do and 6 more

Erratum issuedOpen access · bronzeAbstract readValidation Study
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 100 citations in OpenAlex.

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  8. Updating and validating the Figueroa Frailty Index: transitioning from ICD-9 to ICD-10.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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  13. Small Strokes, Big Impact: Excessive Mortality After Acute Ischemic Stroke in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
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  17. Evaluating Frailty Index Integrity: Insights from an International Network Study.medRxiv : the preprint server for health sciences · 2026
    Article
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

David ChengBiostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Clark DuMontierNew England ‡, GRECC (Geriatrics Research, Education and Clinical Center), VA Boston Healthcare System, Massachusetts, USA.
Cenk YildirimMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, USA.
Brian CharestMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, USA.
Chelsea E HawleyNew England ‡, GRECC (Geriatrics Research, Education and Clinical Center), VA Boston Healthcare System, Massachusetts, USA.
Min ZhuoDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Julie M PaikNew England ‡, GRECC (Geriatrics Research, Education and Clinical Center), VA Boston Healthcare System, Massachusetts, USA.
Enzo YaksicMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, USA.
J Michael GazianoDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nhan DoBoston VA Cooperative Studies Program, Massachusetts, USA.
Mary BrophyMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, USA.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, USA.
Dae H KimHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.ORCID 0000-0001-7290-6838
Jane A DriverNew England ‡, GRECC (Geriatrics Research, Education and Clinical Center), VA Boston Healthcare System, Massachusetts, USA.
Nathanael R FillmoreMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, USA.ORCID 0000-0002-8058-3423
Ariela R OrkabyNew England ‡, GRECC (Geriatrics Research, Education and Clinical Center), VA Boston Healthcare System, Massachusetts, USA.ORCID 0000-0002-4297-6306
VA Boston Healthcare System · USBrigham and Women's Hospital · USHarvard University · USBoston University · USHebrew SeniorLife · US

Funding

Trageting the Multiple Myeloma EpigenomeP50CA100707 · NCI · DANA-FARBER CANCER INSTITUTE · PI MUNSHI, NIKHIL C. · 2003 to 2023
$45.0M
Targeting Genomic Instability and Evolution in MyelomaP01CA155258 · NCI · DANA-FARBER CANCER INST · PI Charles B Epstein · 2011 to 2026
$32.5M
Preparing For What Is Next With Aducanumab In Real World SettingsR33AG057806 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Christopher Barrett Bowling, Ana Roman Quinones · 2018 to 2026
$9.0M
Translational Researchin Aging Trainnig ProgramT32AG023480 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2004 to 2024
$7.6M
RESEARCH TRAINING IN NEPHROLOGYT32DK007199 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI POLLAK, MARTIN R. · 1986 to 2022
$6.0M
Prospective Monitoring of Newly Approved Cardiovascular Drugs in Older Adults with FrailtyR01AG062713 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KIM, DAE HYUN · 2019 to 2022
$2.8M
Frailty, Statins, and Cardiovascular Disease Burden in Older AdultsR03AG060169 · NIA · HARVARD MEDICAL SCHOOL · PI ORKABY, ARIELA R · 2018 to 2019
$193k
MOLECULAR MANIPULATION TO ENHANCE ANTI-MYELOMA RESPONSEI01BX001584 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MUNSHI, NIKHIL C. · 2013 to 2025
–
Statins for Primary Prevention of Cardiovascular Disease and FrailtyIK2CX001800 · VA · VA BOSTON HEALTH CARE SYSTEM · PI ORKABY, ARIELA R · 2019 to 2023
–
BLRD VA I01 BX001584CSRD VA IK2 CX001800CSRD VA IK2 CX002218NCI NIH HHS P01 CA155258NCI NIH HHS P50 CA100707NIA NIH HHS R01 AG062713NIA NIH HHS R03 AG060169NIA NIH HHS R33 AG057806NIA NIH HHS T32 AG023480NIDDK NIH HHS T32 DK007199
6 · The paper itself

Abstract

backgroundThe Veterans Affairs Frailty Index (VA-FI) is an electronic frailty index developed to measure frailty using administrative claims and electronic health records data in Veterans. An update to ICD-10 coding is needed to enable contemporary measurement of frailty.

methodInternational Classification of Diseases, ninth revision (ICD-9) codes from the original VA-FI were mapped to ICD-10 first using the Centers for Medicaid and Medicare Services (CMS) General Equivalence Mappings. The resulting ICD-10 codes were reviewed by 2 geriatricians. Using a national cohort of Veterans aged 65 years and older, the prevalence of deficits contributing to the VA-FI and associations between the VA-FI and mortality over years 2012-2018 were examined.

resultsThe updated VA-FI-10 includes 6422 codes representing 31 health deficits. Annual cohorts defined on October 1 of each year included 2 266 191 to 2 428 115 Veterans, for which the mean age was 76 years, 97%-98% were male, 78%-79% were White, and the mean VA-FI was 0.20-0.22. The VA-FI-10 deficits showed stability before and after the transition to ICD-10 in 2015, and maintained strong associations with mortality. Patients classified as frail (VA-FI > 0.2) consistently had a hazard of death more than 2 times higher than nonfrail patients (VA-FI ≤ 0.1). Distributions of frailty and associations with mortality varied with and without linkage to CMS data and with different assessment periods for capturing deficits.

conclusionsThe updated VA-FI-10 maintains content validity, stability, and predictive validity for mortality in a contemporary cohort of Veterans aged 65 years and older, and may be applied to ICD-9 and ICD-10 claims data to measure frailty.

Indexed as

International Classification of DiseasesAgedFrailtyHumansMaleUnited StatesUnited States Department of Veterans AffairsVeteransClaims-based frailty indexElectronic frailty indexEpidemiologyFrailtyICD 9–ICD-10 transition

Identifiers

PMID33693638
PMCPMC8202143
OpenAlexW3135361384

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.