ArticleBrain : a journal of neurology2021
Travelling waves reveal a dynamic seizure source in human focal epilepsy.
Article in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Robust time delay estimation for measurement of ictal EEG traveling waves.Journal of neural engineering · 2026Article
- Traveling waves along the cortical depth reflect structured synaptic inputs.Research square · 2026Article
- Integrating data across oscillatory power bands predicts the seizure onset zone in focal epilepsies.Brain communications · 2026Article
- Ephaptic conduction molding memory engrams.BMC biology · 2025Article
- Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings.STAR protocols · 2025Article
- Stereo-EEG propagating source reconstruction identifies new surgical targets for epilepsy patients.Brain : a journal of neurology · 2025Article
- Reproducibility of temporally evolving seizure patterns and network connectivity in focal epilepsy.Frontiers in neurology · 2025Article
- Focal seizures induce spatiotemporally organized spiking activity in the human cortex.Nature communications · 2024Article
- A spatial perturbation framework to validate implantation of the epileptogenic zone.Nature communications · 2024Article
- Ephaptic conduction in tonic-clonic seizures.Frontiers in neurology · 2024Article
- Identifying sources of human interictal discharges with travelling wave and white matter propagation.Brain : a journal of neurology · 2023Article
- Interictal discharges in the human brain are travelling waves arising from an epileptogenic source.Brain : a journal of neurology · 2023Article
- Ictal source localization from intracranial recordings.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Graph theoretical measures of fast ripples support the epileptic network hypothesis.Brain communications · 2022Article
- Wheels Within Wheels: Theory and Practice of Epileptic Networks.Epilepsy currents · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Treatment of patients with drug-resistant focal epilepsy relies upon accurate seizure localization. Ictal activity captured by intracranial EEG has traditionally been interpreted to suggest that the underlying cortex is actively involved in seizures. Here, we hypothesize that such activity instead reflects propagated activity from a relatively focal seizure source, even during later time points when ictal activity is more widespread. We used the time differences observed between ictal discharges in adjacent electrodes to estimate the location of the hypothesized focal source and demonstrated that the seizure source, localized in this manner, closely matches the clinically and neurophysiologically determined brain region giving rise to seizures. Moreover, we determined this focal source to be a dynamic entity that moves and evolves over the time course of a seizure. Our results offer an interpretation of ictal activity observed by intracranial EEG that challenges the traditional conceptualization of the seizure source.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.