ArticleAmerican journal of epidemiology2021
Associations of Body Composition and Physical Activity Level With Multiple Measures of Epigenetic Age Acceleration.
Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Epigenetic Age Acceleration as a Modifiable Public Health Target: A Systematic Review and Meta-Analysis of Environmental, Behavioral, and Social Determinants with Development of the MEAB-Index.International journal of molecular sciences · 2026Pooled it
- Exercise and nutrition as epigenetic regulators of gene expression: an exploratory scoping review with bibliometric analysis.Frontiers in nutrition · 2026Pooled it
- Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025Pooled it
- BMI is positively associated with accelerated epigenetic aging in twin pairs discordant for body mass index.Journal of internal medicine · 2022Pooled it
- Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.Nature aging · 2025Trial
- High-Intensity interval training reduces transcriptomic age: A randomized controlled trial.Aging cell · 2023Trial
- Epigenetic age deceleration reflects exercise-induced cardiorespiratory fitness improvements.GeroScience · 2026Article
- Associations of breast DNA methylation-based measures of biological ageing with obesity-related breast cancer risk markers.Epigenetics · 2026Article
- Social media use duration and epigenetic aging among U.S. adults in the MIDUS refresher study.PLOS digital health · 2026Article
- DXA-Measured Visceral Adipose Tissue and Accelerated Biological Aging in Middle-Aged Adults.Obesity (Silver Spring, Md.) · 2026Article
- Association of muscle mass and strength with blood-based epigenetic aging among middle-aged and older adults in the United States.GeroScience · 2026Article
- Association between biological aging and coronary heart disease: A secondary analysis of two observational studies.iScience · 2026Article
- Does leisure activity matter for epigenetic aging? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study.Innovation in aging · 2026Article
- Cumulative Epigenetic Aging From Birth to Young Adulthood and Prospective Associations With Cardiometabolic Health in the CHAMACOS Study.Journal of the American Heart Association · 2025Article
- Does frequency or diversity of leisure activity matter more for epigenetic ageing? Analyses of arts engagement and physical activity.medRxiv : the preprint server for health sciences · 2025Article
- Association of longitudinal body mass index trajectories with phenotypic age acceleration: a cross-sectional study based on growth mixture modeling.GeroScience · 2025Article
- Review
- [Association between DNA methylation clock and obesity-related indicators: A longitudinal twin study].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Active longevity and aging: dissecting the impacts of physical and sedentary behaviors on longevity and age acceleration.GeroScience · 2025Observational
- Construction and validation of a DNN-based biological age and its influencing factors in the China Kadoorie Biobank.GeroScience · 2025Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
Epigenetic clocks use DNA methylation to estimate biological age. Whether body composition and physical activity are associated with these clocks is not well understood. Using blood samples collected at enrollment (2003-2009) from 2,758 women in the US nationwide Sister Study, we calculated 6 epigenetic age acceleration metrics using 4 epigenetic clocks (Hannum, Horvath, PhenoAge, GrimAge). Recreational physical activity was self-reported, and adiposity measures were assessed by trained medical examiners (body mass index (BMI), waist-to-hip ratio (WtH), waist circumference). In cross-sectional analyses, all adiposity measures were associated with epigenetic age acceleration. The strongest association was for BMI and PhenoAge, a measure of biological age that correlates with chronic disease (BMI of ≥35.0 vs. 18.5-24.9, β = 3.15 years, 95% confidence interval (CI): 2.41, 3.90; P for trend < 0.001). In a mutual-adjustment model, both were associated with PhenoAge age acceleration (BMI of ≥35.0 vs. 18.5-24.9, β = 2.69 years, 95% CI: 1.90, 3.48; P for trend < 0.001; quartile 4 vs.1 WtH, β = 1.00 years, 95% CI: 0.34, 1.65; P for trend < 0.008). After adjustment, physical activity was associated only with GrimAge (quartile 4 vs. 1, β = -0.42 years, 95% CI: -0.70, -0.14; P for trend = 0.001). Physical activity attenuated the waist circumference associations with PhenoAge and GrimAge. Excess adiposity was associated with epigenetic age acceleration; physical activity might attenuate associations with waist circumference.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.