Evidence map›Paper›PMID 33693542›Full record

ReviewChemical senses2021

A Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies.

Dany Gaillard, Linda A Barlow

Abstract readReview
In one paragraph

Review in Chemical senses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Identification of symptom clusters and sentinel symptoms in preoperative patients with oral and maxillofacial cancers: A cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
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  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dany GaillardDepartment of Cell & Developmental Biology, and the Rocky Mountain Taste & Smell Center, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8108, Aurora, CO 80045, USA.ORCID 0000-0002-6875-025X
Linda A BarlowDepartment of Cell & Developmental Biology, and the Rocky Mountain Taste & Smell Center, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8108, Aurora, CO 80045, USA.

Funding

Mechanisms of Adult Taste Bud RegenerationR01DC012383 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI BARLOW, LINDA A · 2012 to 2021
$3.4M
Characterization of progenitor populations in adult taste epitheliumR01DC018489 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI BARLOW, LINDA A · 2020 to 2024
$2.5M
Effect of head and neck irradiation on taste cell renewal and Wnt signalingR21DC016131 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI GAILLARD, DANY · 2017 to 2019
$560k
Use of lingual organoids to screen for the impact of targeted cancer therapies on taste bud renewalR21CA236480 · NCI · UNIVERSITY OF COLORADO DENVER · PI BARLOW, LINDA A · 2019 to 2020
$372k
NCI NIH HHS R21 CA236480NIDCD NIH HHS R01 DC012383NIDCD NIH HHS R01 DC018489NIDCD NIH HHS R21 DC016131
6 · The paper itself

Abstract

Since the early 20th century, progress in cancer therapies has significantly improved disease prognosis. Nonetheless, cancer treatments are often associated with side effects that can negatively affect patient well-being and disrupt the course of treatment. Among the main side effects, taste impairment is associated with depression, malnutrition, and morbid weight loss. Although relatively common, taste disruption associated with cancer therapies remains poorly understood. Here, we review the current knowledge related to the molecular mechanisms underlying taste maintenance and disruption in the context of cancer therapies.

Indexed as

AnimalsAntineoplastic AgentsHumansNeoplasmsTaste BudsAntineoplastic AgentschemotherapyHedgehog signalingNotch signalingorganoidsradiotherapyWnt signaling

Identifiers

PMID33693542
PMCPMC8253380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.