ArticleAmerican journal of clinical pathology2021
The Utility of Liver Biopsy in the Evaluation of Liver Disease and Abnormal Liver Function Tests.
Article in American journal of clinical pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Diagnostic Impact of Liver Biopsy Among Antinuclear Antibody Positive Individuals With Mild Liver Enzyme Elevation.Alimentary pharmacology & therapeutics · 2026Article
- Uncovering silent carriers: Hematological insights and viral burden in incidentally detected hepatitis B virus infection.World journal of hepatology · 2026Article
- Diagnostic Utility of Liver Biopsy in Persistent Unexplained Liver Enzyme Elevation: A Retrospective Cohort Study.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Diagnostic yield and adverse events of liver biopsy in intensive-care-unit patients: a multicenter retrospective observational cohort study.Annals of intensive care · 2025Article
- Liver Biopsy - An Essential LiFT in the Diagnosis of Unexplained Liver Disease.Digestive diseases and sciences · 2025Article
- Unexplained Chronically Elevated Aminotransferases: Liver Biopsy Gives Major Information with Therapeutic Implication in One Patient Out of Seven.Digestive diseases and sciences · 2025Article
- Complications of image-guided liver biopsies: Results of a nationwide database analysis.PloS one · 2025Article
- New Biomarkers in Liver Fibrosis: A Pass through the Quicksand?Journal of personalized medicine · 2024Review
- The Diagnostic Value of Liver Biopsy for Unexplained Liver Dysfunction: A Retrospective Study.Journal of multidisciplinary healthcare · 2024Article
- Distinction of Drug-Induced Liver Injury From Autoimmune Hepatitis in Patients With Acute Liver Injury: Proposal of a Combination of Diagnostic Scores.Gastro hep advances · 2023Article
- Beneficial effect of ursodeoxycholic acid in patients with acyl-CoA oxidase 2 (ACOX2) deficiency-associated hypertransaminasemia.Hepatology (Baltimore, Md.) · 2022Article
- A single-center experience: Liver biopsy results during a year.Hepatology forum · 2022Article
- Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients.Pathogens (Basel, Switzerland) · 2022Article
- The potential roles of interleukin-25 in infectious diseases.Frontiers in immunology · 2022Review
- Adenovirus Hepatitis in Immunocompetent Adults.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe aimed to assess the value of liver biopsy in the evaluation of abnormal liver tests.
methodsWe analyzed consecutive liver biopsy specimens performed for evaluation of unexplained abnormal liver tests from 2014 to 2018. Diagnoses were categorized histologically and clinically. We determined whether histologic examination led to a specific diagnosis and whether prebiopsy laboratory variables predicted the underlying etiology.
resultsAmong the 383 liver biopsy specimens included, chronic hepatitis was the most common histologic (25%) and clinical (17%) diagnosis. Liver biopsy led to a clinical diagnosis in 87% of patients. The most likely clinical diagnoses were autoimmune hepatitis, nonalcoholic fatty liver disease, and drug-induced liver injury (38, 33, and 32 patients, respectively). Using sensitivity, specificity, and positive and negative predictive values, we found that liver tests were not predictive of a specific diagnosis. In patients with no history of liver disease or clinical features of portal hypertension, biopsy specimens revealed histologic cirrhosis in 5% of patients.
conclusionsHistopathologic diagnoses were made in 85% of patients undergoing liver biopsy for investigation of unexplained liver tests, leading to a clinical diagnosis in 87% of patients. However, neither liver tests themselves nor their patterns were useful in predicting histologic or clinical diagnoses.
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