Evidence map›Paper›PMID 33693067›Full record

ArticleBioprinting (Amsterdam, Netherlands)2020

Fiber engraving for bioink bioprinting within 3D printed tissue engineering scaffolds.

Luis Diaz-Gomez, Maryam E Elizondo, Gerry L Koons, Mani Diba, Letitia K Chim, Elizabeth Cosgriff-Hernandez, Anthony J Melchiorri, Antonios G Mikos

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioprinting (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. New Frontiers in 3D Printing Using Biocompatible Polymers.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Multi-Dimensional Printing for Bone Tissue Engineering.Advanced healthcare materials · 2021
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Luis Diaz-GomezDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA.
Maryam E ElizondoDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA.
Gerry L KoonsDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA.
Mani DibaDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA.
Letitia K ChimDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA.
Elizabeth Cosgriff-HernandezDepartment of Biomedical Engineering, University of Texas at Austin, 107 W Dean Keeton Street, Austin, TX, 78712, USA.
Anthony J MelchiorriDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA.
Antonios G MikosDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA.
Rice University · USThe University of Texas at Austin · US

Funding

Training and Dissemination CoreP41EB023833 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI FISHER, JOHN P, MIKOS, ANTONIOS G. · 2017 to 2021
$6.2M
NIBIB NIH HHS P41 EB023833
6 · The paper itself

Abstract

In this work, we describe a new 3D printing methodology for the fabrication of multimaterial scaffolds involving the combination of thermoplastic extrusion and low temperature extrusion of bioinks. A fiber engraving technique was used to create a groove on the surface of a thermoplastic printed fiber using a commercial 3D printer and a low viscosity bioink was deposited into this groove. In contrast to traditional extrusion bioinks that rely on increased viscosity to prevent lateral spreading, this groove creates a defined space for bioink deposition. By physically constraining bioink spreading, a broader range of viscosities can be used. As proof-of-concept, we fabricated and characterized a multimaterial scaffold containing poly(ε-caprolactone) (PCL) as the thermoplastic polymer and a gelatin-based bioink. A 7.5 w/v% gelatin methacryloyl (GelMA) bioink loaded with either 5 w/v% poly(lactic-co-glycolic acid) (PLGA) microparticles containing fluorescent albumin or mouse fibroblasts (1 × 10

Indexed as

3D printingBiofabricationCo-printingEngravingTissue engineering

Identifiers

PMID33693067
PMCPMC7943183
OpenAlexW3000486077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.