Evidence map›Paper›PMID 33692937›Full record

ArticleFrontiers in oncology2020

Analysis of miRNA-mRNA Crosstalk in Radiation-Induced Mouse Thymic Lymphomas to Identify miR-486 as a Critical Regulator by Targeting IGF2BP3 mRNA.

Hainan Zhao, Suhe Dong, Jicong Du, Penglin Xia, Ruling Liu, Tingting Liu, Yajie Yang, Ying Cheng, Jianming Cai, Cong Liu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. IGF2BPs as novel mGenes & diseases · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Hainan ZhaoDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Suhe DongPLA Rocket Force Characteristic Medical Center, Beijing, China.
Jicong DuDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Penglin XiaDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Ruling LiuDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Tingting LiuDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Yajie YangCollege of Basic Medicine, Second Military Medical University, Shanghai, China.
Ying ChengDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Jianming CaiDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Cong LiuDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Fu GaoDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Hu LiuDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Second Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ionizing radiation is one of the common environmental carcinogens. miRNAs play critical roles in the processes of tumor occurrence, development, metastasis. However, the relationship between radiation-induced carcinogenesis and miRNA rarely reported. This study is aimed to investigate the effect of miRNAs on radiation-induced carcinogenesis. In this study we established the radiation-induced thymic lymphoma mice model. By using miRNA array of RTL tissue and predicting for miRNAs target genes, a miRNA-mRNA crosstalk network was established. Based on this network, we identified a critical miRNA, miR-486, which was the most down-regulated in the radiation-induced carcinogenesis. Then the function of miR-486 was confirmed by using knockout mice and cellular experiments. As a result, miR-486 could inhibit proliferation of mouse lymphoma cells by targeting IGF2BP3 mRNA. The adenovirus over-expression miR-486 vector reduced tumorigenesis

Indexed as

IGF2BP3ionizing radiationmiR-486miRNA-mRNA regulatory networkradiation-induced thymic lymphoma

Identifiers

PMID33692937
PMCPMC7938314
OpenAlexW3131046193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.