Evidence map›Paper›PMID 33692777›Full record

ArticleFrontiers in immunology2020

Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers.

Ismaïl Hendaoui, Ahlem Lahmar, Luca Campo, Sihem Mebarki, Sandrine Bichet, Daniel Hess, Martin Degen, Nidhameddine Kchir, Leila Charrada-Ben Farhat, Rania Hefaiedh and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Ismaïl HendaouiFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Ahlem LahmarDepartment of Pathology, Mongi Slim University Hospital, La Marsa, Tunisia.
Luca CampoFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Sihem MebarkiFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Sandrine BichetFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Daniel HessFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Martin DegenLaboratory for Oral Molecular Biology, Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland.
Nidhameddine KchirMedical School, University of Tunis El Manar, Tunis, Tunisia.
Leila Charrada-Ben FarhatMedical School, University of Tunis El Manar, Tunis, Tunisia.
Rania HefaiedhDepartment of Hepato-gastro-enterology, Mongi Slim University Hospital, Tunis, Tunisia.
Christian RuizInstitute of Pathology, University Hospital Basel, Basel, Switzerland.
Luigi M TerraccianoInstitute of Pathology, University Hospital Basel, Basel, Switzerland.
Richard P TuckerDepartment of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA, United States.
Lotfi HendaouiMedical School, University of Tunis El Manar, Tunis, Tunisia.
Ruth Chiquet-EhrismannFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Friedrich Miescher Institute · CHHôpital Mongi Slim · TNUniversity Hospital of Basel · CHTunis El Manar University · TNUniversity of Basel · CHUniversity of Bern · CHUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasis from carcinomas of the gallbladder (n = 4) for the expression of the extracellular matrix glycoproteins tenascin-C and tenascin-W. Anti-tenascin-C and anti-tenascin-W immunoreactivity was found in all biliary tract tumors examined. Unlike tenascin-C, tenascin-W was not detected in normal hepatobiliary tissue. Tenascin-W was also expressed by the cholangiocarcinoma-derived cell line Huh-28. However, co-culture of Huh-28 cells with immortalized bone marrow-derived stromal cells was necessary for the formation and organization of tenascin-W fibrils

Indexed as

Biliary Tract NeoplasmsBiomarkers, TumorCell Line, TumorHumansNeoplasm ProteinsStromal CellsTenascinBiomarkers, TumorNeoplasm ProteinsTenascintenascin-W, humanextracellular matrixgallbladder cancertenascin-Ctenascin-Ntenascin-Wtumor stroma

Identifiers

PMID33692777
PMCPMC7937617
OpenAlexW3130533812

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.